用于治疗性蛋白质递送的刺激响应性纳米材料。
Stimuli-responsive nanomaterials for therapeutic protein delivery.
作者信息
Lu Yue, Sun Wujin, Gu Zhen
机构信息
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA; Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA; Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
出版信息
J Control Release. 2014 Nov 28;194:1-19. doi: 10.1016/j.jconrel.2014.08.015. Epub 2014 Aug 21.
Protein therapeutics have emerged as a significant role in treatment of a broad spectrum of diseases, including cancer, metabolic disorders and autoimmune diseases. The efficacy of protein therapeutics, however, is limited by their instability, immunogenicity and short half-life. In order to overcome these barriers, tremendous efforts have recently been made in developing controlled protein delivery systems. Stimuli-triggered release is an appealing and promising approach for protein delivery and has made protein delivery with both spatiotemporal- and dosage-controlled manners possible. This review surveys recent advances in controlled protein delivery of proteins or peptides using stimuli-responsive nanomaterials. Strategies utilizing both physiological and external stimuli are introduced and discussed.
蛋白质疗法已在治疗包括癌症、代谢紊乱和自身免疫性疾病在内的多种疾病中发挥重要作用。然而，蛋白质疗法的疗效受到其不稳定性、免疫原性和短半衰期的限制。为了克服这些障碍，最近在开发可控蛋白质递送系统方面付出了巨大努力。刺激触发释放是一种有吸引力且有前景的蛋白质递送方法，它使蛋白质递送能够以时空和剂量控制的方式实现。本文综述了使用刺激响应性纳米材料进行蛋白质或肽的可控蛋白质递送的最新进展。介绍并讨论了利用生理和外部刺激的策略。
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