关于关键顶复门入侵配体——顶膜抗原1作用的见解与争议

Insights and controversies into the role of the key apicomplexan invasion ligand, Apical Membrane Antigen 1.

作者信息

Harvey Katherine L, Yap Alan, Gilson Paul R, Cowman Alan F, Crabb Brendan S

机构信息

Centre for Biomedical Research, Burnet Institute, 85 Commercial Road, Melbourne, Victoria 3004, Australia; Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3010, Australia.

Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3010, Australia; Infection and Immunity Division, Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3052, Australia.

出版信息

Int J Parasitol. 2014 Oct 15;44(12):853-7. doi: 10.1016/j.ijpara.2014.08.001. Epub 2014 Aug 23.

DOI:10.1016/j.ijpara.2014.08.001

PMID:25157917

Abstract

Apicomplexan parasites are obligate intracellular pathogens that cause a host of human and animal diseases. These parasites have developed a universal mechanism of invasion involving formation of a 'moving junction' that provides a stable anchoring point through which the parasite invades host cells. The composition of the moving junction, particularly the presence of the protein Apical Membrane Antigen 1 (AMA1), has recently been the subject of some controversy. In this commentary we review findings that led to the current model of the moving junction complex and dissect the major conflicts to determine whether a substantial reassessment of the role of AMA1 is justified.

摘要

顶复门寄生虫是专性细胞内病原体，可引发一系列人类和动物疾病。这些寄生虫已形成一种普遍的入侵机制，涉及形成一个“移动连接”，该连接提供一个稳定的锚定点，寄生虫通过此点侵入宿主细胞。移动连接的组成，特别是顶端膜抗原1（AMA1）蛋白的存在，最近成为了一些争议的焦点。在这篇评论中，我们回顾了导致当前移动连接复合体模型的研究结果，并剖析了主要的争议点，以确定对AMA1作用进行实质性重新评估是否合理。