在手性路易斯酸催化下，用硼氢化钾溶液对α-氨基酮进行不对称还原。

Asymmetric reduction of α-amino ketones with a KBH4 solution catalyzed by chiral Lewis acids.

作者信息

He Peng, Zheng Haifeng, Liu Xiaohua, Lian Xiangjin, Lin Lili, Feng Xiaoming

机构信息

Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (P. R. China), Fax: (+86) 28-8541-8249.

出版信息

Chemistry. 2014 Oct 13;20(42):13482-6. doi: 10.1002/chem.201404732. Epub 2014 Sep 15.

DOI:10.1002/chem.201404732

PMID:25223259

Abstract

An efficient enantioselective reduction of α-amino ketones with potassium borohydride solution catalyzed by chiral N,N'-dioxide-metal complex catalysts was accomplished under mild reaction conditions for the first time. It provided a simple, convenient, and practical approaches for obtaining synthetically important chiral β-amino alcohols in good to excellent yields (up to 98%) and enantioselectivities (up to 97% ee).

摘要

首次在手性N，N'-二氧化物-金属络合物催化剂催化下，使用硼氢化钾溶液在温和反应条件下实现了α-氨基酮的高效对映选择性还原。它为以良好至优异的产率（高达98%）和对映选择性（高达97% ee）获得具有重要合成意义的手性β-氨基醇提供了一种简单、方便且实用的方法。