不对称细胞分裂在酿酒酵母寿命控制中的作用。
Role of asymmetric cell division in lifespan control in Saccharomyces cerevisiae.
作者信息
Higuchi-Sanabria Ryo, Pernice Wolfgang M A, Vevea Jason D, Alessi Wolken Dana M, Boldogh Istvan R, Pon Liza A
机构信息
Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
出版信息
FEMS Yeast Res. 2014 Dec;14(8):1133-46. doi: 10.1111/1567-1364.12216. Epub 2014 Oct 13.
Abstract
Aging determinants are asymmetrically distributed during cell division in S. cerevisiae, which leads to production of an immaculate, age-free daughter cell. During this process, damaged components are sequestered and retained in the mother cell, and higher functioning organelles and rejuvenating factors are transported to and/or enriched in the bud. Here, we will describe the key quality control mechanisms in budding yeast that contribute to asymmetric cell division of aging determinants including mitochondria, endoplasmic reticulum (ER), vacuoles, extrachromosomal rDNA circles (ERCs), and protein aggregates.
摘要
衰老决定因素在酿酒酵母细胞分裂过程中不对称分布，这导致产生一个完美无龄的子细胞。在此过程中，受损成分被隔离并保留在母细胞中，而功能更高级的细胞器和年轻化因子则被运输到芽中并/或在芽中富集。在这里，我们将描述出芽酵母中的关键质量控制机制，这些机制有助于衰老决定因素的不对称细胞分裂，包括线粒体、内质网（ER）、液泡、染色体外rDNA环（ERC）和蛋白质聚集体。
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