儿童特应性皮炎：临床特征、病理生理学及治疗
Atopic dermatitis in children: clinical features, pathophysiology, and treatment.
作者信息
Lyons Jonathan J, Milner Joshua D, Stone Kelly D
机构信息
Genetics and Pathophysiology of Allergy Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Genetics and Pathophysiology of Allergy Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
出版信息
Immunol Allergy Clin North Am. 2015 Feb;35(1):161-83. doi: 10.1016/j.iac.2014.09.008. Epub 2014 Nov 21.
Abstract
Atopic dermatitis (AD) is a chronic, relapsing, highly pruritic skin condition resulting from disruption of the epithelial barrier and associated immune dysregulation in the skin of genetically predisposed hosts. AD generally develops in early childhood, has a characteristic age-dependent distribution and is commonly associated with elevated IgE, peripheral eosinophilia, and other allergic diseases. Medications such as antihistamines have demonstrated poor efficacy in controlling AD-associated itch. Education of patients regarding the primary underlying defects and provision of a comprehensive skin care plan is essential for disease maintenance and management of flares.
摘要
特应性皮炎（AD）是一种慢性、复发性、高度瘙痒的皮肤病，由遗传易感性宿主皮肤中的上皮屏障破坏和相关免疫失调引起。AD通常在儿童早期发病，具有特征性的年龄依赖性分布，并且通常与IgE升高、外周嗜酸性粒细胞增多以及其他过敏性疾病相关。抗组胺药等药物在控制AD相关瘙痒方面疗效不佳。对患者进行关于主要潜在缺陷的教育并提供全面的皮肤护理计划对于疾病维持和发作管理至关重要。
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