土耳其青少年和成人百日咳的流行病学
Epidemiology of pertussis in adolescents and adults in Turkey.
作者信息
Karagul A, Ogunc D, Midilli K, Ongut G, Ozhak Baysan B, Donmez L, Daglar D, Kuskucu M A, Bingol A, Ozbudak O, Colak D, Gunseren F
机构信息
Department of Clinical Microbiology,Akdeniz University Faculty of Medicine,Antalya,Turkey.
Department of Clinical Microbiology,Istanbul University Cerrahpasa Faculty of Medicine,İstanbul,Turkey.
出版信息
Epidemiol Infect. 2015 Sep;143(12):2613-8. doi: 10.1017/S0950268814003483. Epub 2014 Dec 19.
Two hundred and fourteen patients who had a cough illness lasting at least 2 weeks were studied to investigate Bordetella pertussis as a cause of prolonged cough in adolescents and adults. Medical history and nasopharyngeal swab specimens for culture and polymerase chain reaction (PCR) were obtained at presentation. Three (1·4%) patients were B. pertussis culture-positive; 15 (7%) were B. pertussis PCR-positive (including the culture-positive patients) and 11 (5·1%) were Bordetella spp. PCR-positive. Symptom combinations were significantly high both in patients with pertussis and patients with indeterminate results (P < 0·05). We conclude that B. pertussis should be considered among differential diagnoses of prolonged cough in adolescents and adults and PCR and culture should be used to detect these cases and facilitate public health response.
对214例咳嗽持续至少2周的患者进行了研究，以调查百日咳博德特氏菌作为青少年和成人持续性咳嗽病因的情况。就诊时获取了病史以及用于培养和聚合酶链反应（PCR）的鼻咽拭子标本。3例（1.4%）患者百日咳博德特氏菌培养阳性；15例（7%）患者百日咳博德特氏菌PCR阳性（包括培养阳性患者），11例（5.1%）患者博德特氏菌属PCR阳性。百日咳患者和结果不确定患者的症状组合均显著偏高（P<0.05）。我们得出结论，在青少年和成人持续性咳嗽的鉴别诊断中应考虑百日咳博德特氏菌，应使用PCR和培养来检测这些病例并促进公共卫生应对。
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