组织驻留记忆T细胞
Tissue-resident memory T cells.
作者信息
Schenkel Jason M, Masopust David
机构信息
Department of Microbiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Department of Microbiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
出版信息
Immunity. 2014 Dec 18;41(6):886-97. doi: 10.1016/j.immuni.2014.12.007. Epub 2014 Dec 6.
Tissue-resident memory T (Trm) cells constitute a recently identified lymphocyte lineage that occupies tissues without recirculating. They provide a first response against infections reencountered at body surfaces, where they accelerate pathogen clearance. Because Trm cells are not present within peripheral blood, they have not yet been well characterized, but are transcriptionally, phenotypically, and functionally distinct from recirculating central and effector memory T cells. In this review, we will summarize current knowledge of Trm cell ontogeny, regulation, maintenance, and function and will highlight technical considerations for studying this population.
组织驻留记忆T（Trm）细胞是最近发现的一类淋巴细胞谱系，它们定位于组织中而不再循环。它们对在体表再次遇到的感染提供初始反应，加速病原体清除。由于Trm细胞不存在于外周血中，它们尚未得到充分表征，但在转录、表型和功能上与循环的中枢和效应记忆T细胞不同。在本综述中，我们将总结目前关于Trm细胞的发生、调控、维持和功能的知识，并强调研究这一细胞群体的技术考量。
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