钌（II）催化的2-芳基苯酚与炔烃通过C-H活化/去芳构化策略进行的氧化螺环化反应。
Ru(II)-catalyzed oxidative spiroannulation of 2-arylphenols with alkynes via a C-H activation/dearomatization strategy.
作者信息
Zuo Zhijun, Yang Xin, Liu Jingjing, Nan Jiang, Bai Lu, Wang Yaoyu, Luan Xinjun
出版信息
J Org Chem. 2015 Mar 20;80(6):3349-56. doi: 10.1021/acs.joc.5b00316. Epub 2015 Mar 5.
PMID:25723782
Abstract
An intermolecular spiroannulation reaction of appropriately substituted 2-arylphenols with internal alkynes has been developed by using a Ru(II) catalyst and an oxidant. This transformation was realized by a phenol-directed C-H activation, migratory insertion of the alkyne, and subsequent dearomatization of the phenolic ring, providing a broad range of highly functionalized spirocyclic compounds in moderate yields with high regioselectivity.
摘要
通过使用钌（II）催化剂和氧化剂，已开发出一种适当取代的2-芳基苯酚与内炔的分子间螺环化反应。这种转化是通过苯酚导向的C-H活化、炔烃的迁移插入以及随后酚环的去芳构化实现的，以中等产率和高区域选择性提供了多种高度官能化的螺环化合物。
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