感染细胞会将其杀手召唤到犯罪现场。

Infected cells call their killers to the scene of the crime.

机构信息

Department of Microbiology and Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.

出版信息

Immunity. 2015 Mar 17;42(3):399-401. doi: 10.1016/j.immuni.2015.03.001.

DOI:10.1016/j.immuni.2015.03.001

Abstract

Effector CD8(+) T cells scan tissues to locate and kill infected host cells. In this issue of Immunity, Hickman et al. (2015) show that the exploration is not random: infected monocytes attract their assassins by secreting chemokines, which accelerates clearance of epicutaneous vaccinia virus infection.

摘要

效应性 CD8(+) T 细胞扫描组织以定位和杀伤感染的宿主细胞。在本期《免疫》中，Hickman 等人（2015 年）表明这种探索并非随机的：受感染的单核细胞通过分泌趋化因子吸引它们的杀手，从而加速清除表皮牛痘病毒感染。