Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands.
Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Gut. 2015 Oct;64(10):1637-49. doi: 10.1136/gutjnl-2014-309086. Epub 2015 Jun 3.
Colorectal cancer (CRC) ranks third among the most commonly diagnosed cancers worldwide, with wide geographical variation in incidence and mortality across the world. Despite proof that screening can decrease CRC incidence and mortality, CRC screening is only offered to a small proportion of the target population worldwide. Throughout the world there are widespread differences in CRC screening implementation status and strategy. Differences can be attributed to geographical variation in CRC incidence, economic resources, healthcare structure and infrastructure to support screening such as the ability to identify the target population at risk and cancer registry availability. This review highlights issues to consider when implementing a CRC screening programme and gives a worldwide overview of CRC burden and the current status of screening programmes, with focus on international differences.
结直肠癌(CRC)在全球最常见的癌症中排名第三,其发病率和死亡率在全球范围内存在广泛的地理差异。尽管有证据表明筛查可以降低 CRC 的发病率和死亡率,但全球只有一小部分目标人群接受 CRC 筛查。在全球范围内,CRC 筛查的实施状况和策略存在广泛差异。这些差异归因于 CRC 发病率的地理差异、经济资源、医疗保健结构和支持筛查的基础设施,例如识别高危目标人群和癌症登记处的可用性。本综述强调了在实施 CRC 筛查计划时需要考虑的问题,并概述了全球 CRC 负担和当前筛查计划的状况,重点关注国际差异。