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乳腺癌与职业:采取行动的必要性:美国公共卫生协会政策声明第20146号,2014年11月18日发布

Breast Cancer and Occupation: The Need for Action: APHA Policy Statement Number 20146, Issued November 18, 2014.

出版信息

New Solut. 2015 Aug;25(2):242-52. doi: 10.1177/1048291115589808. Epub 2015 Jun 15.

Abstract

Breast cancer is the most prevalent cancer among women in the United States and other countries, making it a major public health concern. Despite significant scientific evidence about its known or suspected causes, research and prevention measures to identify and eliminate occupational and other environmental hazards and risk factors for breast cancer remain largely overlooked. As a result, hazards continue unabated for women generally, especially those who work outside the home. The science linking breast cancer and occupation in particular is growing. Researchers have identified commonly used chemicals that induce breast tumors in test animals. Animal studies link chemicals that mimic reproductive hormones to elevated breast cancer rates. Other animal and human studies link chemical exposures to increased breast cancer rates, including two recent investigations focused on occupational hazards. But the latter are the exception. Studies that attempt to identify and characterize workplace agents linked to breast cancer, as well as intervention studies focusing on the use of less toxic processes and substances, are limited. In what might be construed as a case of gender and social class bias, many research and funding agencies have ignored or downplayed the role of occupational studies despite their relevance to prevention efforts. Action required starts with making a national priority of promoting and supporting research on occupational and other environmental causes of breast cancer. Other public health actions include hazard surveillance and primary prevention activities such as reductions in the use of toxic materials, informed substitution, and green chemistry efforts. The original document is accessible at the APHA website, http://www.apha.org/policies-and-advocacy/public-health-policy-statements/policy-database/2015/01/07/14/55/breast-cancer-and-occupation.

摘要

乳腺癌是美国和其他国家女性中最常见的癌症,这使其成为一个重大的公共卫生问题。尽管有大量关于其已知或疑似病因的科学证据,但识别和消除职业及其他环境危害以及乳腺癌风险因素的研究和预防措施在很大程度上仍被忽视。因此,对女性总体而言,危害仍未减弱,尤其是那些外出工作的女性。特别是将乳腺癌与职业联系起来的科学研究正在不断增加。研究人员已经确定了在实验动物中诱发乳腺肿瘤的常用化学物质。动物研究将模拟生殖激素的化学物质与乳腺癌发病率升高联系起来。其他动物和人体研究将化学物质暴露与乳腺癌发病率增加联系起来,包括最近两项关注职业危害的调查。但后者是例外情况。试图识别和描述与乳腺癌相关的工作场所因素的研究,以及专注于使用毒性较小的工艺和物质的干预研究都很有限。在可能被视为性别和社会阶层偏见的情况下,许多研究和资助机构尽管职业研究与预防工作相关,但却忽视或淡化了其作用。所需行动首先要将促进和支持对乳腺癌职业及其他环境病因的研究作为国家优先事项。其他公共卫生行动包括危害监测和初级预防活动,如减少有毒材料的使用、明智的替代以及绿色化学方面的努力。原始文件可在公共卫生协会网站(http://www.apha.org/policies-and-advocacy/public-health-policy-statements/policy-database/2015/01/07/14/55/breast-cancer-and-occupation)上获取。

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