用于体内成像应用的铁（III）选择性螯合增强荧光传感
Iron(III)-Selective Chelation-Enhanced Fluorescence Sensing for In Vivo Imaging Applications.
作者信息
Guo Lin E, Liu Xin Yi, Wang Huan, Chen Qiu Ling, Wang Guang Ke, Luo Kaijun, Mi Qi Li, Zhou Ying, Zhang Jun Feng
机构信息
College of Chemical Science and Technology, Yunnan University, Kunming, 650091, China.
College of Life Science, Yunnan University, Kunming, 650091, China.
出版信息
Chem Asian J. 2015 Sep;10(9):1898-902. doi: 10.1002/asia.201500415. Epub 2015 Jul 31.
A "turn-on" pattern Fe(3+) -selective fluorescent sensor was synthesized and characterized that showed high fluorescence discrimination of Fe(3+) over Fe(2+) and other tested ions. With a 62-fold fluorescence enhancement towards Fe(3+) , the probe was employed to detect Fe(3+) in vivo in HeLa cells and Caenorhabditis elegans, and it was also successfully used to elucidate Fe(3+) enrichment and exchange infected by innexin3 (Inx3) in hemichannel-closed Sf9 cells.
合成并表征了一种“开启”型Fe(3+)选择性荧光传感器，该传感器对Fe(3+)相对于Fe(2+)和其他测试离子表现出高荧光选择性。该探针在HeLa细胞和秀丽隐杆线虫体内对Fe(3+)有62倍的荧光增强，可用于检测Fe(3+)，还成功用于阐明半通道封闭的Sf9细胞中因innexin3（Inx3）感染导致的Fe(3+)富集和交换情况。
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