肥大细胞的产生以及对白细胞介素-4和白细胞介素-13的反应。
Mast cell production and response to IL-4 and IL-13.
作者信息
McLeod Jamie J A, Baker Bianca, Ryan John J
机构信息
Department of Biology, Virginia Commonwealth University Richmond, VA 23284, United States.
Department of Biology, Virginia Commonwealth University Richmond, VA 23284, United States.
出版信息
Cytokine. 2015 Sep;75(1):57-61. doi: 10.1016/j.cyto.2015.05.019. Epub 2015 Jun 15.
Abstract
IL-4 was identified as the first cytokine to be produced by mast cells and is responsible for promoting mast cell IL-13 production. IL-4 and IL-13 play a prominent role in stimulating and maintaining the allergic response. As closely related genes, IL-4 and IL-13 share a common receptor subunit, IL-4Rα, necessary for signaling. Here we summarize the literature on mast cell activation associated with IL-4 and IL-13 production, including downstream signaling. We also describe the positive and negative roles each cytokine plays in mast cell immunity and detail the differences that exist between mouse and human mast cell responses to IL-4 and IL-13.
摘要
白细胞介素-4被确定为肥大细胞产生的第一种细胞因子，负责促进肥大细胞产生白细胞介素-13。白细胞介素 -4和白细胞介素-13在刺激和维持过敏反应中起重要作用。作为密切相关的基因，白细胞介素-4和白细胞介素-13共享一个共同的受体亚基——信号传导所必需的白细胞介素-4受体α。在这里，我们总结了与白细胞介素-4和白细胞介素-13产生相关的肥大细胞活化的文献，包括下游信号传导。我们还描述了每种细胞因子在肥大细胞免疫中所起的正负作用，并详细说明了小鼠和人类肥大细胞对白细胞介素-4和白细胞介素-13反应之间存在的差异。
相似文献
1
Mast cell production and response to IL-4 and IL-13.
Cytokine. 2015 Sep;75(1):57-61. doi: 10.1016/j.cyto.2015.05.019. Epub 2015 Jun 15.
2
T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production.
Cytokine. 2015 Sep;75(1):14-24. doi: 10.1016/j.cyto.2015.05.010. Epub 2015 Jun 1.
3
IL-4 and IL-13 signaling in allergic airway disease.
Cytokine. 2015 Sep;75(1):68-78. doi: 10.1016/j.cyto.2015.05.014. Epub 2015 Jun 9.
4
Expression of IL-4 receptor alpha on smooth muscle cells is not necessary for development of experimental allergic asthma.
J Allergy Clin Immunol. 2010 Aug;126(2):347-54. doi: 10.1016/j.jaci.2010.04.028. Epub 2010 Jun 25.
5
IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation.
J Immunol. 2009 Nov 15;183(10):6469-77. doi: 10.4049/jimmunol.0901575. Epub 2009 Oct 19.
6
src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation.
J Clin Invest. 2003 Jan;111(1):109-19. doi: 10.1172/JCI15719.
7
Kit activates interleukin-4 receptor and effector signal transducer and activator of transcription 6 independent of its cognate ligand in mouse mast cells.
Immunology. 2020 Apr;159(4):441-449. doi: 10.1111/imm.13174. Epub 2020 Feb 7.
8
Interleukin-4 receptor signaling pathways in asthma pathogenesis.
Trends Mol Med. 2004 Oct;10(10):493-9. doi: 10.1016/j.molmed.2004.08.004.
9
Biology and therapeutic potential of the interleukin-4/interleukin-13 signaling pathway in asthma.
Am J Respir Med. 2002;1(3):185-93. doi: 10.1007/BF03256608.
10
Evolution and function of interleukin-4 receptor signaling in adaptive immunity and neutrophils.
Genes Immun. 2020 May;21(3):143-149. doi: 10.1038/s41435-020-0095-7. Epub 2020 Mar 6.
引用本文的文献
1
Immunohistopathological Analysis of Spongiosis Formation in Atopic Dermatitis Compared with Other Skin Diseases.
Dermatopathology (Basel). 2025 Aug 1;12(3):23. doi: 10.3390/dermatopathology12030023.
2
Wenqing Yin Attenuates the Allergic Contact Dermatitis Response by Inhibiting the JAK2/STAT1 and MAPK Signaling Pathways.
J Inflamm Res. 2025 May 30;18:7013-7031. doi: 10.2147/JIR.S512868. eCollection 2025.
3
Targeting IL-13 and IL-4 in Asthma: Therapeutic Implications on Airway Remodeling in Severe Asthma.
Clin Rev Allergy Immunol. 2025 Apr 21;68(1):44. doi: 10.1007/s12016-025-09045-2.
4
Impact of Newcastle disease virus vaccines and genetic variations on interleukin-4 activation in broiler chicken.
Open Vet J. 2025 Jan;15(1):388-394. doi: 10.5455/OVJ.2025.v15.i1.34. Epub 2025 Jan 31.
5
Omalizumab Treated Urticaria Patients Display T Cell and Thrombocyte-Associated Gene Regulation.
Immun Inflamm Dis. 2025 Feb;13(2):e70132. doi: 10.1002/iid3.70132.
6
Alpha-gal syndrome and the gastrointestinal reaction: a narrative review.
Front Allergy. 2025 Jan 24;6:1535103. doi: 10.3389/falgy.2025.1535103. eCollection 2025.
7
NLRP3 deficiency aggravated DNFB-induced chronic itch by enhancing type 2 immunity IL-4/TSLP-TRPA1 axis in mice.
Front Immunol. 2025 Jan 10;15:1450887. doi: 10.3389/fimmu.2024.1450887. eCollection 2024.
8
Retinoic Acid Regulates Allergic Inflammation via Limiting Mast Cell Activation.
Food Sci Nutr. 2025 Jan 7;13(1):e4727. doi: 10.1002/fsn3.4727. eCollection 2025 Jan.
9
Shrimp allergen extract immunotherapy induces prolonged immune tolerance in a gastro-food allergy mouse model.
PLoS One. 2024 Dec 27;19(12):e0315312. doi: 10.1371/journal.pone.0315312. eCollection 2024.
10
The epithelial era of asthma research: knowledge gaps and future direction for patient care.
Eur Respir Rev. 2024 Dec 18;33(174). doi: 10.1183/16000617.0221-2024. Print 2024 Oct.
本文引用的文献
1
MicroRNA-143 downregulates interleukin-13 receptor alpha1 in human mast cells.
Int J Mol Sci. 2013 Aug 19;14(8):16958-69. doi: 10.3390/ijms140816958.
2
Intraperitoneal influx of neutrophils in response to IL-33 is mast cell-dependent.
Blood. 2013 Jan 17;121(3):530-6. doi: 10.1182/blood-2012-05-434209. Epub 2012 Oct 23.
3
Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice.
Allergy. 2012 Sep;67(9):1118-26. doi: 10.1111/j.1398-9995.2012.02859.x. Epub 2012 Jun 15.
4
Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis.
J Immunol. 2012 May 1;188(9):4360-8. doi: 10.4049/jimmunol.1003223. Epub 2012 Mar 26.
5
IL-33 induces skin inflammation with mast cell and neutrophil activation.
Eur J Immunol. 2011 Aug;41(8):2229-37. doi: 10.1002/eji.201041360. Epub 2011 Jun 24.
6
Akt cross-links IL-4 priming, stem cell factor signaling, and IgE-dependent activation in mature human mast cells.
Mol Immunol. 2011 Jan;48(4):546-52. doi: 10.1016/j.molimm.2010.10.010. Epub 2010 Nov 23.
7
Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma.
Eur Respir Rev. 2010 Mar;19(115):46-54. doi: 10.1183/09059180.00007609.
8
IL-4 and TGF-beta 1 counterbalance one another while regulating mast cell homeostasis.
J Immunol. 2010 May 1;184(9):4688-95. doi: 10.4049/jimmunol.0903477. Epub 2010 Mar 19.
9
Mechanisms of mast cell signaling in anaphylaxis.
J Allergy Clin Immunol. 2009 Oct;124(4):639-46; quiz 647-8. doi: 10.1016/j.jaci.2009.08.035.
10
Endogenous suppression of mast cell development and survival by IL-4 and IL-10.
J Leukoc Biol. 2009 May;85(5):826-36. doi: 10.1189/jlb.0708448. Epub 2009 Feb 19.
Zotero 插件