溶质载体转运蛋白作为治疗靶点：新出现的机会
SLC transporters as therapeutic targets: emerging opportunities.
作者信息
Lin Lawrence, Yee Sook Wah, Kim Richard B, Giacomini Kathleen M
机构信息
Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, California 94158, USA.
Division of Clinical Pharmacology, Department of Medicine, University of Western Ontario, London Health Science Centre, London, Ontario N6A 5A5, Canada.
出版信息
Nat Rev Drug Discov. 2015 Aug;14(8):543-60. doi: 10.1038/nrd4626. Epub 2015 Jun 26.
Solute carrier (SLC) transporters - a family of more than 300 membrane-bound proteins that facilitate the transport of a wide array of substrates across biological membranes - have important roles in physiological processes ranging from the cellular uptake of nutrients to the absorption of drugs and other xenobiotics. Several classes of marketed drugs target well-known SLC transporters, such as neurotransmitter transporters, and human genetic studies have provided powerful insight into the roles of more-recently characterized SLC transporters in both rare and common diseases, indicating a wealth of new therapeutic opportunities. This Review summarizes knowledge on the roles of SLC transporters in human disease, describes strategies to target such transporters, and highlights current and investigational drugs that modulate SLC transporters, as well as promising drug targets.
溶质载体（SLC）转运蛋白是一类超过300种的膜结合蛋白，可促进多种底物跨生物膜的转运，在从细胞对营养物质的摄取到药物及其他外源性物质的吸收等生理过程中发挥着重要作用。几类已上市药物靶向作用于知名的SLC转运蛋白，如神经递质转运蛋白，而人类遗传学研究为新近鉴定的SLC转运蛋白在罕见病和常见疾病中的作用提供了有力见解，表明存在大量新的治疗机会。本综述总结了关于SLC转运蛋白在人类疾病中作用的知识，描述了靶向此类转运蛋白的策略，并重点介绍了调节SLC转运蛋白的现有药物和研究性药物，以及有前景的药物靶点。
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