HIV-1的组装、释放与成熟。
HIV-1 assembly, release and maturation.
作者信息
Freed Eric O
机构信息
Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Bg. 535, Room 110, 1050 Boyles St., Frederick, Maryland 21702-1201, USA.
出版信息
Nat Rev Microbiol. 2015 Aug;13(8):484-96. doi: 10.1038/nrmicro3490. Epub 2015 Jun 29.
Abstract
Major advances have occurred in recent years in our understanding of HIV-1 assembly, release and maturation, as work in this field has been propelled forwards by developments in imaging technology, structural biology, and cell and molecular biology. This increase in basic knowledge is being applied to the development of novel inhibitors designed to target various aspects of virus assembly and maturation. This Review highlights recent progress in elucidating the late stages of the HIV-1 replication cycle and the related interplay between virology, cell and molecular biology, and drug discovery.
摘要
近年来，我们对HIV-1组装、释放和成熟的理解取得了重大进展，因为成像技术、结构生物学以及细胞与分子生物学的发展推动了该领域的研究工作。这些基础知识的增加正被应用于开发旨在靶向病毒组装和成熟各个方面的新型抑制剂。本综述重点介绍了在阐明HIV-1复制周期后期以及病毒学、细胞与分子生物学和药物发现之间的相关相互作用方面的最新进展。
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本文引用的文献
1
HIV-1 capsid: the multifaceted key player in HIV-1 infection.
Nat Rev Microbiol. 2015 Aug;13(8):471-83. doi: 10.1038/nrmicro3503.
2
STRUCTURAL VIROLOGY. X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability.
Science. 2015 Jul 3;349(6243):99-103. doi: 10.1126/science.aaa5936. Epub 2015 Jun 4.
3
HIV-1 gag: an emerging target for antiretroviral therapy.
Curr Top Microbiol Immunol. 2015;389:171-201. doi: 10.1007/82_2015_436.
4
Angiomotin functions in HIV-1 assembly and budding.
Elife. 2015 Jan 29;4:e03778. doi: 10.7554/eLife.03778.
5
Maturation of the HIV-1 core by a non-diffusional phase transition.
Nat Commun. 2015 Jan 8;6:5854. doi: 10.1038/ncomms6854.
6
Structural basis of HIV-1 capsid recognition by PF74 and CPSF6.
Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18625-30. doi: 10.1073/pnas.1419945112. Epub 2014 Dec 17.
7
Global changes in the RNA binding specificity of HIV-1 gag regulate virion genesis.
Cell. 2014 Nov 20;159(5):1096-1109. doi: 10.1016/j.cell.2014.09.057. Epub 2014 Nov 6.
8
Cytoplasmic HIV-1 RNA is mainly transported by diffusion in the presence or absence of Gag protein.
Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):E5205-13. doi: 10.1073/pnas.1413169111. Epub 2014 Nov 17.
9
Structure of the immature HIV-1 capsid in intact virus particles at 8.8 Å resolution.
Nature. 2015 Jan 22;517(7535):505-8. doi: 10.1038/nature13838. Epub 2014 Nov 2.
10
Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly.
PLoS Pathog. 2014 Oct 30;10(10):e1004459. doi: 10.1371/journal.ppat.1004459. eCollection 2014 Oct.
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