Bandeen-Roche Karen, Seplaki Christopher L, Huang Jin, Buta Brian, Kalyani Rita R, Varadhan Ravi, Xue Qian-Li, Walston Jeremy D, Kasper Judith D
Department of Biostatistics, Bloomberg School of Public Health and Center on Aging and Health, Johns Hopkins University, Baltimore, Maryland. Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland.
Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, New York.
J Gerontol A Biol Sci Med Sci. 2015 Nov;70(11):1427-34. doi: 10.1093/gerona/glv133. Epub 2015 Aug 21.
Frailty assessment provides a means of identifying older adults most vulnerable to adverse outcomes. Attention to frailty in clinical practice is more likely with better understanding of its prevalence and associations with patient characteristics. We sought to provide national estimates of frailty in older people.
A popular, validated frailty phenotype proposed by Fried and colleagues was applied to 7,439 participants in the 2011 baseline of the National Health and Aging Trends Study, a national longitudinal study of persons aged 65 and older. All measures drew on a 2-hour in-person interview. Weighted estimates of frailty prevalence were obtained.
Fifteen percent (95% CI: 14%, 16%) of the older non-nursing home population is frail, and 45% is prefrail (95% CI: 44%, 47%). Frailty is more prevalent at older ages, among women, racial and ethnic minorities, those in supportive residential settings, and persons of lower income. Independently of these characteristics, frailty prevalence varies substantially across geographic regions. Chronic disease and disability prevalence increase steeply with frailty. Among the frail, 42% were hospitalized in the previous year, compared to 22% of the prefrail and 11% of persons considered robust. Hip, back, and heart surgery in the last year were associated with frailty. Over half of frail persons had a fall in the previous year.
Our findings support the importance of frailty in late-life health etiology and potential value of frailty as a marker of risk for adverse health outcomes and as a means of identifying opportunities for intervention in clinical practice and public health policy.
衰弱评估提供了一种识别最易出现不良后果的老年人的方法。随着对其患病率以及与患者特征之间关联的更好理解,临床实践中对衰弱的关注可能会更多。我们试图提供老年人衰弱情况的全国性估计数据。
Fried及其同事提出的一种广受欢迎且经过验证的衰弱表型应用于国家健康与老龄化趋势研究2011年基线的7439名参与者,该研究是一项针对65岁及以上人群的全国性纵向研究。所有测量均基于为期2小时的面对面访谈。获得了衰弱患病率的加权估计值。
15%(95%置信区间:14%,16%)的非养老院老年人群体衰弱,45%处于衰弱前期(95%置信区间:44%,47%)。衰弱在老年人、女性、少数种族和族裔、居住在支持性住所的人群以及低收入人群中更为普遍。独立于这些特征之外,衰弱患病率在不同地理区域之间存在很大差异。慢性病和残疾患病率随着衰弱程度急剧上升。在衰弱人群中,42%在过去一年中曾住院治疗,相比之下衰弱前期人群为22%,健康人群为11%。去年进行髋关节、背部和心脏手术与衰弱有关。超过一半的衰弱人群在过去一年中曾跌倒。
我们的研究结果支持了衰弱在晚年健康病因学中的重要性,以及衰弱作为不良健康结局风险标志物和在临床实践与公共卫生政策中识别干预机会手段的潜在价值。