肥胖对端粒长度的影响：系统评价与荟萃分析。
Effect of obesity on telomere length: Systematic review and meta-analysis.
作者信息
Mundstock Eduardo, Sarria Edgar E, Zatti Helen, Mattos Louzada Fernanda, Kich Grun Lucas, Herbert Jones Marcus, Guma Fátima T C R, Mazzola In Memoriam João, Epifanio Matias, Stein Renato T, Barbé-Tuana Florencia M, Mattiello Rita
机构信息
Pontifícia Universidade Católica Do Rio Grande Do Sul (PUCRS). Departament: Centro Infant, Biomedical Research Institute, Porto Alegre, Brazil.
School of Medicine, Department of Biology and Pharmacy, Universidade De Santa Cruz Do Sul (UNISC), Santa Cruz, Brazil.
出版信息
Obesity (Silver Spring). 2015 Nov;23(11):2165-74. doi: 10.1002/oby.21183. Epub 2015 Sep 26.
OBJECTIVE
The main objective of this systematic review is to assess the effects of obesity on telomere length.
METHODS
The following databases were searched: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library), LILACS, SPORTdiscus, and Web of Science from inception to August 2014. The search was performed using the following combinations of terms: telomere AND "overweight" OR "obesity" OR "adiposity," without language restriction.
RESULTS
Sixty-three original studies were included in this systematic review, comprising 119,439 subjects. Thirty-nine studies showed either weak or moderate correlation between obesity and telomere length; however, they showed an important heterogeneity.
CONCLUSIONS
There is a tendency toward demonstrating negative correlation between obesity and telomere length. The selected studies showed weak to moderate correlation for the main search, and there was an important heterogeneity. For this reason, the causal relationship of obesity and telomere length remains open. Additional controlled longitudinal studies are needed to investigate this issue.
目的
本系统评价的主要目的是评估肥胖对端粒长度的影响。
方法
检索了以下数据库：从建库至2014年8月的MEDLINE、EMBASE、Cochrane对照试验中心注册库（CENTRAL，Cochrane图书馆）、拉丁美洲及加勒比地区卫生科学数据库（LILACS）、体育与运动医学数据库（SPORTdiscus）和科学引文索引（Web of Science）。检索采用以下术语组合：端粒与“超重”或“肥胖”或“肥胖症”，无语言限制。
结果
本系统评价纳入了63项原始研究，共119439名受试者。39项研究表明肥胖与端粒长度之间存在弱或中度相关性；然而，它们显示出重要的异质性。
结论
有证据表明肥胖与端粒长度之间呈负相关。所选研究在主要检索中显示出弱至中度相关性，且存在重要的异质性。因此，肥胖与端粒长度之间的因果关系仍未明确。需要更多的对照纵向研究来调查这个问题。
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