成年哺乳动物神经干细胞与神经发生：五十年后
Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later.
作者信息
Bond Allison M, Ming Guo-Li, Song Hongjun
机构信息
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
出版信息
Cell Stem Cell. 2015 Oct 1;17(4):385-95. doi: 10.1016/j.stem.2015.09.003.
Adult somatic stem cells in various organs maintain homeostatic tissue regeneration and enhance plasticity. Since its initial discovery five decades ago, investigations of adult neurogenesis and neural stem cells have led to an established and expanding field that has significantly influenced many facets of neuroscience, developmental biology, and regenerative medicine. Here we review recent progress and focus on questions related to adult mammalian neural stem cells that also apply to other somatic stem cells. We further discuss emerging topics that are guiding the field toward better understanding adult neural stem cells and ultimately applying these principles to improve human health.
各种器官中的成体体细胞干细胞维持着组织的稳态再生并增强可塑性。自五十年前首次发现以来，对成体神经发生和神经干细胞的研究已形成了一个不断发展壮大的领域，该领域对神经科学、发育生物学和再生医学的许多方面都产生了重大影响。在此，我们回顾近期的进展，并聚焦于与成年哺乳动物神经干细胞相关的问题，这些问题也适用于其他体细胞干细胞。我们还将讨论一些新兴话题，这些话题正引领该领域更好地理解成年神经干细胞，并最终应用这些原理来改善人类健康。
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