双酚A致癌潜力综述。
A review of the carcinogenic potential of bisphenol A.
作者信息
Seachrist Darcie D, Bonk Kristen W, Ho Shuk-Mei, Prins Gail S, Soto Ana M, Keri Ruth A
机构信息
Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106-4965, USA.
Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267-0056, USA.
出版信息
Reprod Toxicol. 2016 Jan;59:167-82. doi: 10.1016/j.reprotox.2015.09.006. Epub 2015 Oct 19.
The estrogenic properties of bisphenol A (BPA), a ubiquitous synthetic monomer that can leach into the food and water supply, have prompted considerable research into exposure-associated health risks in humans. Endocrine-disrupting properties of BPA suggest it may impact developmental plasticity during early life, predisposing individuals to disease at doses below the oral reference dose (RfD) established by the Environmental Protection Agency in 1982. Herein, we review the current in vivo literature evaluating the carcinogenic properties of BPA. We conclude that there is substantial evidence from rodent studies indicating that early-life BPA exposures below the RfD lead to increased susceptibility to mammary and prostate cancer. Based on the definitions of "carcinogen" put forth by the International Agency for Research on Cancer and the National Toxicology Program, we propose that BPA may be reasonably anticipated to be a human carcinogen in the breast and prostate due to its tumor promoting properties.
双酚A（BPA）是一种普遍存在的合成单体，可渗入食物和水源中，其雌激素特性促使人们对其与人类健康风险相关的暴露进行了大量研究。BPA的内分泌干扰特性表明，它可能会影响生命早期的发育可塑性，使个体在低于美国环境保护局1982年确定的口服参考剂量（RfD）的剂量下易患疾病。在此，我们综述了目前评估BPA致癌特性的体内研究文献。我们得出结论，啮齿动物研究有大量证据表明，生命早期低于RfD的BPA暴露会增加患乳腺癌和前列腺癌的易感性。根据国际癌症研究机构和美国国家毒理学计划提出的“致癌物”定义，我们认为，由于BPA具有促肿瘤特性，合理预期它可能是人类乳腺癌和前列腺癌的致癌物。
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