一种基于罗丹明 - 苯并咪唑的铁（Ⅲ）化学传感器及其在活细胞中的应用
A Rhodamine-Benzimidazole Based Chemosensor for Fe(3+) and its Application in Living Cells.
作者信息
Li Gongchun, Tang Jun, Ding Peigang, Ye Yong
机构信息
School of Chemistry and Chemical Engineering, Xuchang University, Xuchang, 461000, China.
Phosphorus Chemical Engineering Research Center of Henan Province, The College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450052, China.
出版信息
J Fluoresc. 2016 Jan;26(1):155-61. doi: 10.1007/s10895-015-1696-9. Epub 2015 Oct 30.
A rhodamine-benzimidazole based chemosensor was designed and prepared for Fe(3+) via opening of the spiro-ring to give fluorescent and colored species. L exhibited high selectivity and excellent sensitivity in both absorbance and fluorescence detection of Fe(3+) in aqueous solution with comparatively wide pH range (5.8-7.4). The detection limit of this newly developed probe was shown to be up to 2.74 μM. The reversibility establishes the potential of both probes as chemosensors for Fe(3+) detection. Fluorescence imaging experiments of Fe(3+) in living MGC803 cells demonstrated its value of practical applications in biological systems.
设计并制备了一种基于罗丹明 - 苯并咪唑的化学传感器，通过螺环开环用于检测Fe(3+)，生成荧光和显色物质。L在较宽的pH范围（5.8 - 7.4）的水溶液中，对Fe(3+)的吸光度和荧光检测均表现出高选择性和优异的灵敏度。新开发的该探针的检测限高达2.74 μM。其可逆性确立了这两种探针作为Fe(3+)检测化学传感器的潜力。在活的MGC803细胞中对Fe(3+)进行的荧光成像实验证明了其在生物系统中的实际应用价值。
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