Castillo María Esther, Bada Carlos, Del Aguila Olguita, Petrozzi-Helasvuo Verónica, Casabona-Ore Verónica, Reyes Isabel, Del Valle-Mendoza Juana
Instituto Nacional de Salud del Niño, Breña, Lima, Peru.
Hospital de Emergencias Pediátricas, La Victoria, Lima, Peru.
Int J Infect Dis. 2015 Dec;41:36-41. doi: 10.1016/j.ijid.2015.10.020. Epub 2015 Oct 30.
To report the incidence, epidemiology, and clinical features of Bordetella pertussis in Peruvian infants under 1 year old.
A prospective cross-sectional study was conducted in five hospitals in Peru from January 2010 to July 2012. A total of 392 infants under 1 year old were admitted with a clinical diagnosis of whooping cough and tested for B. pertussis by PCR.
The pertussis toxin and IS481 genes were detected in 39.54% (155/392) of the cases. Infants aged less than 3 months were the most affected, with a prevalence of 73.55% (114/155). The most common household contact was the mother, identified in 20% (31/155) of cases. Paroxysm of coughing (89.03%, 138/155), cyanosis (68.39%, 106/155), respiratory distress (67.09%, 104/155), and breastfeeding difficulties (39.35%, 61/155) were the most frequent symptoms reported.
An increase in pertussis cases has been reported in recent years in Peru, despite national immunization efforts. Surveillance with PCR for B. pertussis is essential, especially in infants less than 1 year old, in whom a higher rate of disease-related complications and higher mortality have been reported.
报告秘鲁1岁以下婴儿百日咳博德特氏菌的发病率、流行病学及临床特征。
2010年1月至2012年7月在秘鲁的五家医院开展了一项前瞻性横断面研究。共有392名1岁以下婴儿因临床诊断为百日咳入院，并通过聚合酶链反应检测百日咳博德特氏菌。
39.54%（155/392）的病例检测到百日咳毒素和IS481基因。3个月以下婴儿受影响最大，患病率为73.55%（114/155）。最常见的家庭接触者是母亲，在20%（31/155）的病例中被确认。咳嗽发作（89.03%，138/155）、发绀（68.3%，106/155）、呼吸窘迫（67.09%，104/155）和母乳喂养困难（39.35%，61/155）是报告的最常见症状。
尽管国家开展了免疫工作，但近年来秘鲁报告的百日咳病例有所增加。对百日咳博德特氏菌进行聚合酶链反应监测至关重要，尤其是在1岁以下婴儿中，据报告这些婴儿与疾病相关的并发症发生率更高且死亡率更高。
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