海洋药物对肿瘤坏死因子相关凋亡诱导配体（TRAIL）诱导的细胞凋亡的调控作用
Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL).
作者信息
Elmallah Mohammed I Y, Micheau Olivier
机构信息
Department of Chemistry, Faculty of Science, Helwan University, Ain Helwan, Cairo 11790, Egypt.
Institut National de la Santé et de la Recherche Médicale, UMR866, Dijon F-21079, France.
出版信息
Mar Drugs. 2015 Nov 13;13(11):6884-909. doi: 10.3390/md13116884.
Marine biomass diversity is a tremendous source of potential anticancer compounds. Several natural marine products have been described to restore tumor cell sensitivity to TNF-related apoptosis inducing ligand (TRAIL)-induced cell death. TRAIL is involved during tumor immune surveillance. Its selectivity for cancer cells has attracted much attention in oncology. This review aims at discussing the main mechanisms by which TRAIL signaling is regulated and presenting how marine bioactive compounds have been found, so far, to overcome TRAIL resistance in tumor cells.
海洋生物量多样性是潜在抗癌化合物的巨大来源。已有几种天然海洋产物被描述可恢复肿瘤细胞对肿瘤坏死因子相关凋亡诱导配体（TRAIL）诱导的细胞死亡的敏感性。TRAIL参与肿瘤免疫监视过程。其对癌细胞的选择性在肿瘤学领域引起了广泛关注。本综述旨在讨论TRAIL信号传导被调节的主要机制，并介绍迄今为止发现的海洋生物活性化合物如何克服肿瘤细胞中的TRAIL抗性。
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