自然杀伤细胞、衰老与癌症。
Natural killer cells, ageing and cancer.
作者信息
Naumova Elissaveta, Pawelec Graham, Mihaylova Anastasiya
机构信息
Department of Clinical Immunology and Stem Cell Bank, University Hospital "Alexandrovska", Medical University, 1, Georgi Sofiiski str., 1431, Sofia, Bulgaria.
Center for Medical Research (ZMF), University of Tübingen Medical School, Tübingen, Germany.
出版信息
Cancer Immunol Immunother. 2016 Apr;65(4):367-70. doi: 10.1007/s00262-016-1817-6. Epub 2016 Mar 11.
Natural killer (NK) cells are key components of innate immunity and substantially contribute to anti-tumor immune responses. The role of NK cells in immune surveillance is linked to many aspects of NK cell biology, but the age of the animal being studied or the human under treatment is rarely taken into account. The solicited reviews constituting a collection of papers presented here as a "Symposium-in-Writing" on the topic of NK cells, ageing and cancer were inspired by the increasing knowledge of NK cell biology and genetics, and emerging data on their impact in the clinic (disease associations and therapies), together with the realization that older individuals also differ from younger ones regarding innate as well as adaptive immunity.
自然杀伤（NK）细胞是固有免疫的关键组成部分，对抗肿瘤免疫反应有重要贡献。NK细胞在免疫监视中的作用与NK细胞生物学的许多方面相关，但所研究的动物或接受治疗的人类的年龄很少被考虑在内。这里作为关于NK细胞、衰老和癌症主题的“书面研讨会”呈现的一组论文所征集的综述，其灵感来源于对NK细胞生物学和遗传学的了解不断增加，以及它们在临床中的影响（疾病关联和治疗）方面的新出现的数据，同时也认识到老年人在固有免疫和适应性免疫方面也与年轻人不同。
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