在中国，全细胞疫苗已使用 50 年，成人百日咳血清阳性率。
Seroprevalence of pertussis among adults in China where whole cell vaccines have been used for 50 years.
机构信息
Department of Medical Microbiology, Capital Medical University, Beijing, China.
Beijing Youan Hospital, Capital Medical University, Beijing, China; Collaborative Innovation Center of Infectious Diseases, Capital Medical University, Beijing, China.
出版信息
J Infect. 2016 Jul;73(1):38-44. doi: 10.1016/j.jinf.2016.04.004. Epub 2016 Apr 8.
OBJECTIVE
To estimate the true incidence of pertussis in Chinese adults who are at a childbearing age.
METHODS
A total of 897 serum samples from healthy individuals aged 20-39 years were selected randomly from a large number of serum samples collected in 2010 in Beijing, China. Anti-pertussis toxin (Ptx) IgG antibodies were determined with the Virion/Serion ELISA kits using purified Ptx as a coating antigen.
RESULTS
Only 124 (13.8%) were found to have undetectable anti-Ptx IgG antibodies. The mean concentration was 13.76 IU/ml (95% CI, 12.37-15.15). Forty-six (5.1%) subjects had anti-Ptx IgG levels greater than or equal to 40 IU/ml, indicative of a pertussis infection, and nine (1%) had IgG antibodies greater than or equal to 100 IU/ml, indicative of a recent infection within a year. No significant differences were observed between age groups of 20-29 and 30-39 years, or between genders.
CONCLUSIONS
Our study showed that about 5% of adults aged 20-39 years had positive anti-Ptx IgG antibodies, suggesting that adult pertussis is common in China. Giving a booster vaccination to pregnant women should possibly be considered in order to protect young infants who are too young to be vaccinated in this country.
目的
评估中国育龄期成人百日咳的真实发病率。
方法
从中国北京 2010 年采集的大量血清样本中随机选择 897 份年龄在 20-39 岁的健康个体血清样本。采用 Virion/Serion ELISA 试剂盒，以纯化的百日咳毒素（Ptx）作为包被抗原，检测抗 Ptx 毒素（Ptx）IgG 抗体。
结果
仅 124 例（13.8%）被发现抗 Ptx IgG 抗体不可检测。平均浓度为 13.76 IU/ml（95%CI，12.37-15.15）。46 例（5.1%）受试者的抗 Ptx IgG 水平大于或等于 40 IU/ml，表明存在百日咳感染，9 例（1%）的 IgG 抗体大于或等于 100 IU/ml，表明一年内存在近期感染。20-29 岁和 30-39 岁年龄组以及性别之间无显著差异。
结论
我们的研究表明，约 5%的 20-39 岁成年人具有阳性抗 Ptx IgG 抗体，表明成人百日咳在中国很常见。为了保护该国尚未接种疫苗的年幼婴儿，可能需要考虑为孕妇接种加强疫苗。
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