RNA聚合酶II转录延伸与前体mRNA剪接的偶联
Coupling of RNA Polymerase II Transcription Elongation with Pre-mRNA Splicing.
作者信息
Saldi Tassa, Cortazar Michael A, Sheridan Ryan M, Bentley David L
机构信息
Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, P.O. Box 6511, Aurora, CO 80045, USA.
Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, P.O. Box 6511, Aurora, CO 80045, USA.
出版信息
J Mol Biol. 2016 Jun 19;428(12):2623-2635. doi: 10.1016/j.jmb.2016.04.017. Epub 2016 Apr 20.
Abstract
Pre-mRNA maturation frequently occurs at the same time and place as transcription by RNA polymerase II. The co-transcriptionality of mRNA processing has permitted the evolution of mechanisms that functionally couple transcription elongation with diverse events that occur on the nascent RNA. This review summarizes the current understanding of the relationship between transcriptional elongation through a chromatin template and co-transcriptional splicing including alternative splicing decisions that affect the expression of most human genes.
摘要
前体mRNA的成熟过程通常与RNA聚合酶II的转录过程在同一时间和地点发生。mRNA加工的共转录特性使得一些机制得以进化，这些机制在功能上将转录延伸与新生RNA上发生的各种事件联系起来。本综述总结了目前对于通过染色质模板进行的转录延伸与共转录剪接（包括影响大多数人类基因表达的可变剪接决定）之间关系的理解。
相似文献
1
Coupling of RNA Polymerase II Transcription Elongation with Pre-mRNA Splicing.
J Mol Biol. 2016 Jun 19;428(12):2623-2635. doi: 10.1016/j.jmb.2016.04.017. Epub 2016 Apr 20.
2
The in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicing.
PLoS Biol. 2011 Jan 11;9(1):e1000573. doi: 10.1371/journal.pbio.1000573.
3
Coupling transcription and alternative splicing.
Adv Exp Med Biol. 2007;623:175-89. doi: 10.1007/978-0-387-77374-2_11.
4
Control of alternative pre-mRNA splicing by RNA Pol II elongation: faster is not always better.
IUBMB Life. 2003 Apr-May;55(4-5):235-41. doi: 10.1080/1521654031000119830.
5
Coupling between transcription and alternative splicing.
Cancer Treat Res. 2013;158:1-24. doi: 10.1007/978-3-642-31659-3_1.
6
On the importance of being co-transcriptional.
J Cell Sci. 2002 Oct 15;115(Pt 20):3865-71. doi: 10.1242/jcs.00073.
7
Co-transcriptional regulation of alternative pre-mRNA splicing.
Biochim Biophys Acta. 2012 Jul;1819(7):673-83. doi: 10.1016/j.bbagrm.2012.01.014. Epub 2012 Feb 2.
8
Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factors.
Curr Opin Cell Biol. 2005 Jun;17(3):251-6. doi: 10.1016/j.ceb.2005.04.006.
9
Defective histone supply causes changes in RNA polymerase II elongation rate and cotranscriptional pre-mRNA splicing.
Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14840-5. doi: 10.1073/pnas.1506760112. Epub 2015 Nov 17.
10
Artificial RNA Polymerase II Elongation Complexes for Dissecting Co-transcriptional RNA Processing Events.
J Vis Exp. 2019 May 13(147). doi: 10.3791/59497.
引用本文的文献
1
Alternative Splicing in Embryo Implantation.
Matern Fetal Med. 2025 Apr;7(2):85-94. doi: 10.1097/FM9.0000000000000272. Epub 2025 Feb 24.
2
Introns increase gene expression in Caenorhabditis elegans by a mechanism that must be at least partly different than in plants.
Sci Rep. 2025 May 7;15(1):15862. doi: 10.1038/s41598-025-99739-6.
3
TFE3 fusions drive oxidative metabolism and ferroptosis resistance in translocation renal cell carcinoma.
EMBO Mol Med. 2025 May;17(5):1041-1070. doi: 10.1038/s44321-025-00221-7. Epub 2025 Mar 27.
4
Drosophila ovarian stem cell niche ageing involves coordinated changes in transcription and alternative splicing.
Nat Commun. 2025 Mar 16;16(1):2596. doi: 10.1038/s41467-025-57901-8.
5
YY1 drives PARP1 expression essential for PARylation of NONO in mRNA maturation during neuroblastoma progression.
J Transl Med. 2024 Dec 27;22(1):1153. doi: 10.1186/s12967-024-05956-4.
6
Phenotypic screens identify SCAF1 as critical activator of RNAPII elongation and global transcription.
Nucleic Acids Res. 2025 Feb 8;53(4). doi: 10.1093/nar/gkae1219.
7
Regulation of Alternative Splicing by PARP1 in HTR-8/Svneo Cells: Implications for Placental Development and Spontaneous Abortion.
Curr Med Sci. 2024 Dec;44(6):1325-1336. doi: 10.1007/s11596-024-2943-6. Epub 2024 Nov 20.
8
Regulation of mRNA Biogenesis: The Norm and Pathology.
Int J Mol Sci. 2024 Oct 26;25(21):11493. doi: 10.3390/ijms252111493.
9
Alternative splicing is coupled to gene expression in a subset of variably expressed genes.
NPJ Genom Med. 2024 Nov 4;9(1):54. doi: 10.1038/s41525-024-00432-w.
10
Isoginkgetin and Madrasin are poor splicing inhibitors.
PLoS One. 2024 Oct 21;19(10):e0310519. doi: 10.1371/journal.pone.0310519. eCollection 2024.
本文引用的文献
1
Splicing of Nascent RNA Coincides with Intron Exit from RNA Polymerase II.
Cell. 2016 Apr 7;165(2):372-381. doi: 10.1016/j.cell.2016.02.045. Epub 2016 Mar 24.
2
Defective control of pre-messenger RNA splicing in human disease.
J Cell Biol. 2016 Jan 4;212(1):13-27. doi: 10.1083/jcb.201510032.
3
TET-catalyzed oxidation of intragenic 5-methylcytosine regulates CTCF-dependent alternative splicing.
EMBO J. 2016 Feb 1;35(3):335-55. doi: 10.15252/embj.201593235. Epub 2015 Dec 28.
4
Defective histone supply causes changes in RNA polymerase II elongation rate and cotranscriptional pre-mRNA splicing.
Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14840-5. doi: 10.1073/pnas.1506760112. Epub 2015 Nov 17.
5
Structural analysis of nucleosomal barrier to transcription.
Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):E5787-95. doi: 10.1073/pnas.1508371112. Epub 2015 Oct 12.
6
Splicing inhibition decreases phosphorylation level of Ser2 in Pol II CTD.
Nucleic Acids Res. 2015 Sep 30;43(17):8258-67. doi: 10.1093/nar/gkv740. Epub 2015 Jul 21.
7
FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP.
Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8608-13. doi: 10.1073/pnas.1506282112. Epub 2015 Jun 29.
8
Regulation of alternative splicing through coupling with transcription and chromatin structure.
Annu Rev Biochem. 2015;84:165-98. doi: 10.1146/annurev-biochem-060614-034242.
9
Native elongating transcript sequencing reveals human transcriptional activity at nucleotide resolution.
Cell. 2015 Apr 23;161(3):541-554. doi: 10.1016/j.cell.2015.03.010.
10
Mammalian NET-Seq Reveals Genome-wide Nascent Transcription Coupled to RNA Processing.
Cell. 2015 Apr 23;161(3):526-540. doi: 10.1016/j.cell.2015.03.027.
Zotero 插件