在狼体内发现的微小双RNA病毒之间的重配现象。
Reassortment among picobirnaviruses found in wolves.
作者信息
Conceição-Neto Nádia, Mesquita João Rodrigo, Zeller Mark, Yinda Claude Kwe, Álvares Francisco, Roque Sara, Petrucci-Fonseca Francisco, Godinho Raquel, Heylen Elisabeth, Van Ranst Marc, Matthijnssens Jelle
机构信息
Laboratory of Viral Metagenomics, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, University of Leuven, Leuven, Belgium.
Laboratory for Clinical Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, University of Leuven, Leuven, Belgium.
出版信息
Arch Virol. 2016 Oct;161(10):2859-62. doi: 10.1007/s00705-016-2987-4. Epub 2016 Jul 20.
We conducted a viral metagenomics study in diarrheic free-ranging wolves in Portugal, revealing for the first time the presence of reassortant picobirnaviruses. These viruses shared identical capsid segments together with diverse RNA-dependent RNA polymerase segments. Even though causality between these picobirnaviruses and diarrhea could not be established, the study nonetheless confirms for the first time that wolves are a potential reservoir for picobirnaviruses, which might play a role as enteric pathogens.
我们对葡萄牙腹泻的野生狼进行了病毒宏基因组学研究，首次发现了重配微小双股RNA病毒的存在。这些病毒的衣壳片段相同，但RNA依赖的RNA聚合酶片段各异。尽管无法确定这些微小双股RNA病毒与腹泻之间的因果关系，但该研究首次证实狼是微小双股RNA病毒的潜在宿主，这些病毒可能作为肠道病原体发挥作用。
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