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天然产物的糖基化与活性

Glycosylation and Activities of Natural Products.

作者信息

Huang Gangliang, Lv Meijiao, Hu Jinchuan, Huang Kunlin, Xu Hong

机构信息

College of Chemistry, Chongqing Normal University, Chongqing, 401331, China.

出版信息

Mini Rev Med Chem. 2016;16(12):1013-6. doi: 10.2174/138955751612160727164559.

Abstract

Natural products are widely found in nature, their number and variety are numerous, the structures are complex and diverse. These natural products have many physiological and pharmacological activities. Glycosylation can increase the diversity of structure and function of natural product, it has become the focus of drug research and development. The impacts of glycosylation of natural products to water solubility, pharmacological activities, bioavailability, or others were described in this review, which provides a reference for the development and application of glycosylated natural products.

摘要

天然产物广泛存在于自然界中,其数量和种类繁多,结构复杂多样。这些天然产物具有许多生理和药理活性。糖基化可增加天然产物结构和功能的多样性,已成为药物研发的焦点。本文综述了天然产物糖基化对水溶性、药理活性、生物利用度等方面的影响,为糖基化天然产物的开发与应用提供参考。

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