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颈脊髓和背神经根刺激治疗上肢神经性疼痛

Cervical Spinal Cord and Dorsal Nerve Root Stimulation for Neuropathic Upper Limb Pain.

作者信息

Levine Adrian B, Parrent Andrew G, MacDougall Keith W

机构信息

Department of Clinical Neurological Sciences,Division of Neurosurgery,Western University,London,ON,Canada.

出版信息

Can J Neurol Sci. 2017 Jan;44(1):83-89. doi: 10.1017/cjn.2016.294. Epub 2016 Sep 23.

Abstract

BACKGROUND

Spinal cord stimulation (SCS) is a well-established treatment for chronic neuropathic pain in the lower limbs. Upper limb pain comprises a significant proportion of neuropathic pain patients, but is often difficult to target specifically and consistently with paresthesias. We hypothesized that the use of dorsal nerve root stimulation (DNRS), as an option along with SCS, would help us better relieve pain in these patients.

METHODS

All 35 patients trialed with spinal stimulation for upper limb pain between July 1, 2011, and October 31, 2013, were included. We performed permanent implantation in 23/35 patients based on a visual analogue scale pain score decrease of ≥50% during trial stimulation.

RESULTS

Both the SCS and DNRS groups had significant improvements in average visual analogue scale pain scores at 12 months compared with baseline, and the majority of patients in both groups obtained ≥50% pain relief. The majority of patients in both groups were able to reduce their opioid use, and on average had improvements in Short Form-36 quality of life scores. Complication rates did not differ significantly between the two groups.

CONCLUSIONS

Treatment with SCS or DNRS provides meaningful long-term relief of chronic neuropathic pain in the upper limbs.

摘要

背景

脊髓刺激(SCS)是一种已被广泛认可的治疗下肢慢性神经性疼痛的方法。上肢疼痛在神经性疼痛患者中占相当大的比例,但往往难以通过感觉异常进行特异性和持续性的靶向治疗。我们假设,将背根神经刺激(DNRS)作为SCS的一种补充选择,将有助于我们更好地缓解这些患者的疼痛。

方法

纳入2011年7月1日至2013年10月31日期间接受脊髓刺激治疗上肢疼痛的所有35例患者。根据试验刺激期间视觉模拟量表疼痛评分降低≥50%,我们对35例患者中的23例进行了永久性植入。

结果

与基线相比,SCS组和DNRS组在12个月时的平均视觉模拟量表疼痛评分均有显著改善,两组中的大多数患者疼痛缓解≥50%。两组中的大多数患者能够减少阿片类药物的使用,并且平均而言,简短健康调查问卷-36生活质量评分有所改善。两组的并发症发生率无显著差异。

结论

SCS或DNRS治疗可为上肢慢性神经性疼痛提供有意义的长期缓解。

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