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初次使用阿片类药物的患者在常见手部手术后长期使用阿片类药物的风险。

Risk of Prolonged Opioid Use Among Opioid-Naïve Patients Following Common Hand Surgery Procedures.

作者信息

Johnson Shepard P, Chung Kevin C, Zhong Lin, Shauver Melissa J, Engelsbe Michael J, Brummett Chad, Waljee Jennifer F

机构信息

Department of Surgery, St. Joseph Mercy Ann Arbor, Ann Arbor, MI.

Department of Surgery, Section of Plastic Surgery, University of Michigan Health System, Ann Arbor, MI.

出版信息

J Hand Surg Am. 2016 Oct;41(10):947-957.e3. doi: 10.1016/j.jhsa.2016.07.113. Epub 2016 Sep 28.

Abstract

PURPOSE

To evaluate prolonged opioid use in opioid-naïve patients after common hand surgery procedures in the United States.

METHODS

We studied insurance claims from the Truven MarketScan databases to identify opioid-naïve adult patients (no opioid exposure 11 months before the perioperative period) who underwent an elective (carpal tunnel release, carpometacarpal arthroplasty/arthrodesis, cubital tunnel release, or trigger finger release) or trauma-related (closed distal radius fracture fixation, flexor tendon repair, metacarpal fracture fixation, or phalangeal fracture fixation) hand surgery procedure between 2010 and 2012 (N = 77,573 patients). Patients were observed for 6 months to determine the number, timing, duration, and oral morphine equivalent dosage of postoperative opioid prescriptions. We assessed prolonged postoperative opioid use, defined as patients who filled a perioperative opioid prescription followed by a prescription between 90 and 180 days after surgery, and evaluated associated risk factors using multivariable logistic regression.

RESULTS

In this cohort, 59,725 opioid-naïve patients (77%) filled a perioperative opioid prescription. Of these, 13% of patients continued to fill prescriptions between 90 and 180 days after surgery. Elective surgery patients were more likely to continue to fill opioid prescriptions after 90 days compared with trauma patients (13.5% vs 10.5%). Younger age, female gender, lower income, comprehensive insurance, higher Elixhauser comorbidity index, mental health disorders, and tobacco dependence or abuse were associated with prolonged opioid use.

CONCLUSIONS

Approximately 13% of opioid-naïve patients continue to fill opioid prescriptions after hand surgery procedures 90 days after surgery. Preoperative interventions centered on opioid alternatives and early cessation, particularly among patients at risk for long-term use, is critical to addressing the prescription opioid crisis in the United States.

CLINICAL RELEVANCE

The current national opioid use epidemic requires an assessment of the prevalence of hand surgery patients who receive and fill opioid prescriptions after common hand surgery procedures.

摘要

目的

评估美国普通手部手术后初用阿片类药物患者的阿片类药物长期使用情况。

方法

我们研究了Truven MarketScan数据库中的保险理赔记录,以识别初用阿片类药物的成年患者(围手术期前11个月无阿片类药物暴露史),这些患者在2010年至2012年间接受了择期手术(腕管松解术、腕掌关节成形术/关节固定术、肘管松解术或扳机指松解术)或创伤相关手术(闭合性桡骨远端骨折固定术、屈肌腱修复术、掌骨骨折固定术或指骨骨折固定术)(N = 77,573例患者)。对患者进行6个月的观察,以确定术后阿片类药物处方的数量、时间、持续时间和口服吗啡当量剂量。我们评估了术后阿片类药物的长期使用情况,定义为围手术期开具阿片类药物处方且术后90至180天之间又开具处方的患者,并使用多变量逻辑回归分析相关危险因素。

结果

在该队列中,59,725例初用阿片类药物的患者(77%)开具了围手术期阿片类药物处方。其中,13%的患者在术后90至180天之间继续开具处方。与创伤患者相比,择期手术患者在90天后更有可能继续开具阿片类药物处方(13.5%对10.5%)。年龄较小、女性、收入较低、综合保险、较高的埃利克斯豪泽合并症指数、精神健康障碍以及烟草依赖或滥用与阿片类药物的长期使用有关。

结论

约13%的初用阿片类药物患者在手部手术后90天仍继续开具阿片类药物处方。以阿片类药物替代方案和早期停药为中心的术前干预措施,尤其是在有长期使用风险的患者中,对于解决美国的处方阿片类药物危机至关重要。

临床意义

当前全国性的阿片类药物使用流行情况需要评估普通手部手术后接受并开具阿片类药物处方的患者比例。

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