GAL4系统：一种用于基因表达操纵与分析的多功能系统。

The GAL4 System: A Versatile System for the Manipulation and Analysis of Gene Expression.

作者信息

Caygill Elizabeth E, Brand Andrea H

机构信息

The Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 1QN, UK.

出版信息

Methods Mol Biol. 2016;1478:33-52. doi: 10.1007/978-1-4939-6371-3_2.

DOI:10.1007/978-1-4939-6371-3_2

PMID:27730574

Abstract

Since its introduction in 1993, the GAL4 system has become an essential part of the Drosophila geneticist's toolkit. Widely used to drive gene expression in a multitude of cell- and tissue-specific patterns, the system has been adapted and extended to form the basis of many modern tools for the manipulation of gene expression in Drosophila and other model organisms.

摘要

自1993年引入以来，GAL4系统已成为果蝇遗传学家工具包的重要组成部分。该系统被广泛用于以多种细胞和组织特异性模式驱动基因表达，并且已经得到改进和扩展，以形成许多用于操纵果蝇和其他模式生物中基因表达的现代工具的基础。