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老年人使用苯二氮䓬类药物:危险、管理和替代疗法。

Benzodiazepine Use in Older Adults: Dangers, Management, and Alternative Therapies.

机构信息

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN.

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN.

出版信息

Mayo Clin Proc. 2016 Nov;91(11):1632-1639. doi: 10.1016/j.mayocp.2016.07.024.

Abstract

Several major medical and psychiatric organizations, including the American Geriatrics Society, advise against using benzodiazepines or nonbenzodiazepine hypnotics in older adults. Despite these recommendations, benzodiazepines continue to be massively prescribed to a group with the highest risk of serious adverse effects from these medications. This article summarizes legitimate reasons for prescribing benzodiazepines in the elderly, serious associated risks of prescribing them, particularly when not indicated, barriers physicians encounter in changing their prescription patterns, and evidence-based strategies on how to discontinue benzodiazepines in older patients. Although more research is needed, we propose several alternatives for treating insomnia and anxiety in older adults in primary care settings. These include nonpharmacological approaches such as sleep restriction-sleep compression therapy and cognitive behavioral therapy for anxiety or insomnia, and as well as alternative pharmacological agents.

摘要

包括美国老年医学会在内的几家主要医学和精神病学组织建议,老年患者不要使用苯二氮䓬类药物或非苯二氮䓬类催眠药。尽管有这些建议,但仍有大量的苯二氮䓬类药物被开给这群最容易受到这些药物严重不良反应影响的人群。本文总结了在老年人中开苯二氮䓬类药物的合理理由、在不适当情况下开此类药物的严重相关风险、医生在改变处方模式时遇到的障碍,以及如何在老年患者中停用苯二氮䓬类药物的基于证据的策略。尽管需要更多的研究,但我们在基层医疗环境中为治疗老年人的失眠和焦虑提出了几种替代方案。这些方案包括非药物治疗方法,如睡眠限制-睡眠压缩疗法和焦虑或失眠的认知行为疗法,以及替代药物治疗方法。

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