Callinan Catherine E, Neuman Mark D, Lacy Kim E, Gabison Claudia, Ashburn Michael A
Penn Pain Medicine Center, University of Pennsylvania, Philadelphia, Pennsylvania.
Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania.
J Pain. 2017 Apr;18(4):360-365. doi: 10.1016/j.jpain.2016.11.001. Epub 2016 Dec 3.
This study reports the results of a researcher-administered survey with 115 patients receiving chronic opioid therapy (>90 days) to obtain information regarding how chronic opioid therapy was started. Chronic opioids were started after surgery (27.0%, 95% confidence interval [CI], 18.5-35.5) or for the treatment of acute injury-related pain (27.0%, 95% CI, 18.5-35.5). Many who initiated opioid therapy after surgery reported postoperative complications (61.3%, 95% CI, 50.8-71.8) and many with injury-related pain reported follow-up corrective surgery (58.1%, 95% CI, 47.5-68.7), which led to the continuation of opioids. A large percentage of patients had concurrent depression (43.5%, 95% CI, 34.0-53.0) and anxiety (23.5%, 95% CI, 15.3-31.7). Many participants had a medical history of aberrant drug-related behavior (32.5%, 95% CI, 23.5-41.5) and self-reported history of addiction (21.7%, 95% CI, 13.7-29.7). Almost one-quarter reported taking opioids for a different indication than that for which opioids were started (95% CI, 26.6-45.0). Patients receiving long-term opioid therapy often transitioned to chronic use after starting opioids for the short-term treatment of postoperative or injury-related pain. It is not evident if a clear decision to continue opioids on a chronic basis was made. This survey provides insight as to how chronic opioid therapy is started, and may suggest opportunities for improved patient selection for opioid therapy.
This article explores the reasons why patients using chronic opioid therapy (>90 days) initiated opioid medications. The results of this study may help clinicians better select patients for chronic opioid therapy.
本研究报告了一项由研究人员开展的针对115名接受慢性阿片类药物治疗(超过90天)患者的调查结果,以获取有关慢性阿片类药物治疗起始情况的信息。慢性阿片类药物在术后开始使用(27.0%,95%置信区间[CI],18.5 - 35.5)或用于治疗急性损伤相关疼痛(27.0%,95% CI,18.5 - 35.5)。许多在术后开始阿片类药物治疗的患者报告有术后并发症(61.3%,95% CI,50.8 - 71.8),许多患有损伤相关疼痛的患者报告进行了后续矫正手术(58.1%,95% CI,47.5 - 68.7),这导致阿片类药物持续使用。很大比例的患者同时患有抑郁症(43.5%,95% CI,34.0 - 53.0)和焦虑症(23.5%,95% CI,15.3 - 31.7)。许多参与者有药物相关异常行为的病史(32.5%,95% CI,23.5 - 41.5)以及自我报告的成瘾史(21.7%,95% CI,13.7 - 29.7)。近四分之一的患者报告服用阿片类药物的指征与起始使用阿片类药物的指征不同(95% CI,26.6 - 45.0)。接受长期阿片类药物治疗的患者在为术后或损伤相关疼痛进行短期阿片类药物治疗开始后,常转变为长期使用。是否做出了明确的长期持续使用阿片类药物的决定并不明显。这项调查为慢性阿片类药物治疗的起始情况提供了见解,并可能提示改善阿片类药物治疗患者选择的机会。
本文探讨了使用慢性阿片类药物治疗(超过90天)的患者开始使用阿片类药物的原因。本研究结果可能有助于临床医生更好地选择适合慢性阿片类药物治疗的患者。