成年囊性纤维化患者中铜绿假单胞菌患病率随时间的变化。
Change in Pseudomonas aeruginosa prevalence in cystic fibrosis adults over time.
作者信息
Crull Mathew R, Ramos Kathleen J, Caldwell Ellen, Mayer-Hamblett Nicole, Aitken Moira L, Goss Christopher H
机构信息
Department of Medicine, University of Washington, Seattle, WA, USA.
University of Washington Medical Center, Campus Box 356522, 1959 N.E. Pacific, Seattle, WA, 98195, USA.
出版信息
BMC Pulm Med. 2016 Dec 7;16(1):176. doi: 10.1186/s12890-016-0333-y.
BACKGROUND
Little is known about risk factors for chronic and mucoid Pseudomonas aeruginosa (Pa) infection in cystic fibrosis (CF) adults, and whether the prevalence is changing.
METHODS
We employed a retrospective cohort to analyze data from a single adult CF center (2002 to 2012). Regression models were used to assess independent predictors and change in prevalence of chronic and mucoid Pa infection over time.
RESULTS
The odds ratio of mucoid Pa infection was significantly less in individuals with better baseline lung function (OR 0.84,95%CI:0.77-0.92) and those diagnosed after the age of 25 (OR 0.21, 95%CI:0.05-0.95). The prevalence of chronic Pa and mucoid Pa decreased during the time interval. After adjusting for confounders, the observed decrease in chronic and mucoid Pa between 2002 and 2012 was no longer significant.
CONCLUSIONS
The prevalence of chronic and mucoid Pa is decreasing. Larger studies are needed to confirm these regional trends and their significance.
背景
对于囊性纤维化（CF）成年患者慢性及黏液样铜绿假单胞菌（Pa）感染的危险因素，以及其患病率是否正在发生变化，我们知之甚少。
方法
我们采用回顾性队列研究，分析了来自单一成年CF中心（2002年至2012年）的数据。使用回归模型评估慢性及黏液样Pa感染的独立预测因素以及随时间推移其患病率的变化。
结果
基线肺功能较好的个体（比值比0.84，95%置信区间：0.77 - 0.92）以及25岁以后确诊的个体（比值比0.21，95%置信区间：0.05 - 0.95）发生黏液样Pa感染的比值比显著更低。在该时间段内，慢性Pa和黏液样Pa的患病率有所下降。在对混杂因素进行调整后，2002年至2012年间观察到的慢性及黏液样Pa患病率下降不再显著。
结论
慢性及黏液样Pa的患病率正在下降。需要开展更大规模的研究来证实这些区域趋势及其意义。
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