癌症免疫治疗研究中的“小事聪明大事糊涂”：亟需能反映人类修饰因素的小鼠癌症模型
Being "penny-wise but pound foolish" in cancer immunotherapy research: the urgent need for mouse cancer models to reflect human modifying factors.
作者信息
Murphy William J
机构信息
Departments of Dermatology and Internal Medicine, UC Davis School of Medicine, Sacramento, CA USA.
出版信息
J Immunother Cancer. 2016 Dec 20;4:88. doi: 10.1186/s40425-016-0195-0. eCollection 2016.
Abstract
Inbred mice are the mainstay for preclinical cancer assessment of potential therapeutics, especially immune-based approaches. However, the use of young, lean, inbred mice housed under specific-pathogen-free conditions does not mirror the human cancer scenario. This commentary discusses some of the issues in evaluating immunotherapeutics in mice given recent advances.
摘要
近交系小鼠是潜在治疗药物临床前癌症评估的主要对象，尤其是基于免疫的治疗方法。然而，在无特定病原体条件下饲养的年轻、瘦型近交系小鼠并不能反映人类癌症的情况。鉴于最近的进展，本评论讨论了在小鼠中评估免疫疗法的一些问题。
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