2型糖尿病患者血清微量元素的变化

Alterations of serum trace elements in patients with type 2 diabetes.

作者信息

Zhang Hongmei, Yan Chonghuai, Yang Zhen, Zhang Weiwei, Niu Yixin, Li Xiaoyong, Qin Li, Su Qing

机构信息

Department of Endocrinology, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

出版信息

J Trace Elem Med Biol. 2017 Mar;40:91-96. doi: 10.1016/j.jtemb.2016.12.017. Epub 2017 Jan 9.

DOI:10.1016/j.jtemb.2016.12.017

PMID:28159227

Abstract

OBJECTIVE

The aim of the present study is to investigate the association of trace elements and the risk of type 2 diabetes mellitus.

DESIGN AND METHODS

The 1837 participants (637 men and 1200 women) aged 40-70 were from a cross-sectional community-based study performed in downtown Shanghai. All the participants without diabetes mellitus history underwent a 75-g OGTT. The participants with diabetes mellitus took 100g steamed bread as the substitute. The fasting and OGTT 2h or postprandial 2h venous blood samples were collected. Blood glucose levels, fasting serum insulin concentrations, lipid profiles, HbA1C and 19 trace elements including magnesium, copper, zinc and selenium and so on were assayed.

RESULTS

Of all the 1837 studied subjects, 510 subjects had diabetes mellitus (191 male, 319 female). Serum magnesium levels were decreased statistically (p<0.05), but serum copper, zinc and selenium levels were significantly increased in subjects with diabetes mellitus compared to non-diabetic subjects (p<0.01 for copper, p<0.001 for zinc and selenium). Logistic regression analysis showed that serum magnesium was negatively associated with diabetes (p<0.05) and serum copper, zinc, and selenium were all positively associated with diabetes (p<0.05 for copper, p<0.001 for both zinc and selenium). Correlation analysis showed a remarkable correlation between blood glucose, HbA1C and serum magnesium, copper, zinc, and selenium (p<0.01 for zinc, p<0.001 for copper, zinc and selenium).

CONCLUSIONS

Serum magnesium levels are decreased and serum copper, zinc and selenium levels are elevated in patients with type 2 diabetes mellitus.

摘要

目的

本研究旨在调查微量元素与2型糖尿病风险之间的关联。

设计与方法

1837名年龄在40 - 70岁的参与者（637名男性和1200名女性）来自于在上海市中心开展的一项基于社区的横断面研究。所有无糖尿病病史的参与者均接受了75克口服葡萄糖耐量试验（OGTT）。患有糖尿病的参与者则以100克馒头作为替代。采集空腹及OGTT 2小时或餐后2小时的静脉血样本。检测血糖水平、空腹血清胰岛素浓度、血脂谱、糖化血红蛋白（HbA1C）以及包括镁、铜、锌和硒等在内的19种微量元素。

结果

在所有1837名研究对象中，510名患有糖尿病（191名男性，319名女性）。与非糖尿病受试者相比，糖尿病患者的血清镁水平有统计学意义的降低（p<0.05），而血清铜、锌和硒水平显著升高（铜p<0.01，锌和硒p<0.001）。逻辑回归分析表明血清镁与糖尿病呈负相关（p<0.05），血清铜、锌和硒均与糖尿病呈正相关（铜p<0.05，锌和硒p<0.001）。相关性分析显示血糖、HbA1C与血清镁、铜、锌和硒之间存在显著相关性（锌p<0.01，铜、锌和硒p<0.001）。