转移的新兴生物学原理
Emerging Biological Principles of Metastasis.
作者信息
Lambert Arthur W, Pattabiraman Diwakar R, Weinberg Robert A
机构信息
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology and the MIT Ludwig Center for Molecular Oncology, Cambridge, MA 02142, USA.
出版信息
Cell. 2017 Feb 9;168(4):670-691. doi: 10.1016/j.cell.2016.11.037.
Abstract
Metastases account for the great majority of cancer-associated deaths, yet this complex process remains the least understood aspect of cancer biology. As the body of research concerning metastasis continues to grow at a rapid rate, the biological programs that underlie the dissemination and metastatic outgrowth of cancer cells are beginning to come into view. In this review we summarize the cellular and molecular mechanisms involved in metastasis, with a focus on carcinomas where the most is known, and we highlight the general principles of metastasis that have begun to emerge.
摘要
转移是大多数癌症相关死亡的原因，然而这个复杂的过程仍然是癌症生物学中最不为人所了解的方面。随着有关转移的研究数量持续快速增长，癌细胞扩散和转移生长背后的生物学程序开始逐渐清晰。在这篇综述中，我们总结了转移过程中涉及的细胞和分子机制，重点关注了解最多的 carcinomas（此处原文有误，推测可能是“癌”carcinomas），并强调了已开始显现的转移的一般原则。
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本文引用的文献
1
Surviving at a Distance: Organ-Specific Metastasis.
Trends Cancer. 2015 Sep;1(1):76-91. doi: 10.1016/j.trecan.2015.07.009. Epub 2015 Sep 28.
2
En Route to Metastasis: Circulating Tumor Cell Clusters and Epithelial-to-Mesenchymal Transition.
Trends Cancer. 2015 Sep;1(1):44-52. doi: 10.1016/j.trecan.2015.07.006. Epub 2015 Sep 28.
3
Rab11 collaborates E-cadherin to promote collective cell migration and indicates a poor prognosis in colorectal carcinoma.
Eur J Clin Invest. 2016 Dec;46(12):1002-1011. doi: 10.1111/eci.12683. Epub 2016 Nov 1.
4
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.
Cell. 2016 Aug 25;166(5):1117-1131.e14. doi: 10.1016/j.cell.2016.07.032.
5
Inflammation Triggers Zeb1-Dependent Escape from Tumor Latency.
Cancer Res. 2016 Dec 1;76(23):6778-6784. doi: 10.1158/0008-5472.CAN-16-0608. Epub 2016 Aug 16.
6
Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis.
Nature. 2016 Aug 11;536(7615):215-8. doi: 10.1038/nature19076. Epub 2016 Aug 3.
7
Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility.
Cell. 2016 Jul 14;166(2):328-342. doi: 10.1016/j.cell.2016.05.052. Epub 2016 Jun 30.
8
Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling.
Cell. 2016 Jun 30;166(1):47-62. doi: 10.1016/j.cell.2016.06.009.
9
EMT: 2016.
Cell. 2016 Jun 30;166(1):21-45. doi: 10.1016/j.cell.2016.06.028.
10
Neutrophils in cancer: neutral no more.
Nat Rev Cancer. 2016 Jul;16(7):431-46. doi: 10.1038/nrc.2016.52. Epub 2016 Jun 10.
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