红细胞纳米囊泡：生物发生、生物学作用及治疗方法：红细胞纳米囊泡
Erythrocyte nanovesicles: Biogenesis, biological roles and therapeutic approach: Erythrocyte nanovesicles.
作者信息
Harisa Gamaleldin I, Badran Mohamed M, Alanazi Fars K
机构信息
Kayyali Chair for Pharmaceutical Industry, Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia; Department of Biochemistry, College of Pharmacy, Al-Azhar University, Cairo, Egypt.
Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia; Department of Pharmaceutics, College of Pharmacy, Al-Azhar University, Cairo, Egypt.
出版信息
Saudi Pharm J. 2017 Jan;25(1):8-17. doi: 10.1016/j.jsps.2015.06.010. Epub 2015 Jul 2.
Nanovesicles (NVs) represent a novel transporter for cell signals to modify functions of target cells. Therefore, NVs play many roles in both physiological and pathological processes. This report highlights biogenesis, composition and biological roles of erythrocytes derived nanovesicles (EDNVs). Furthermore, we address utilization of EDNVs as novel drug delivery cargo as well as therapeutic target. EDNVs are lipid bilayer vesicles rich in phospholipids, proteins, lipid raft, and hemoglobin. In vivo EDNVs biogenesis is triggered by an increase of intracellular calcium levels, ATP depletion and under effect of oxidative stress conditions. However, in vitro production of EDNVs can be achieved via hypotonic treatment and extrusion of erythrocyte. NVs can be used as biomarkers for diagnosis, monitoring of therapy and drug delivery system. Many therapeutic agents are suggested to decrease NVs biogenesis.
纳米囊泡（NVs）是一种用于细胞信号传递以改变靶细胞功能的新型转运体。因此，NVs在生理和病理过程中都发挥着多种作用。本报告重点介绍了红细胞衍生纳米囊泡（EDNVs）的生物发生、组成和生物学作用。此外，我们还探讨了EDNVs作为新型药物递送载体以及治疗靶点的应用。EDNVs是富含磷脂、蛋白质、脂筏和血红蛋白的脂质双层囊泡。在体内，EDNVs的生物发生是由细胞内钙水平升高、ATP耗竭以及氧化应激条件的作用引发的。然而，EDNVs的体外生产可以通过低渗处理和红细胞挤压来实现。NVs可作为诊断、治疗监测和药物递送系统的生物标志物。许多治疗剂被认为可以减少NVs的生物发生。
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