一种用于谷氨酸和锌的双输入荧光逻辑门。
A Two-Input Fluorescent Logic Gate for Glutamate and Zinc.
作者信息
Yin Caixia, Huo Fangjun, Cooley Nicholas P, Spencer David, Bartholomew Kyle, Barnes Charles L, Glass Timothy E
机构信息
Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Key Laboratory of Materials for Energy Conversion and Storage of Shanxi Province, Institute of Molecular Science, Shanxi University , Taiyuan 030006, China.
Department of Chemistry, University of Missouri , 601 South College Avenue, Columbia, Missouri 65211, United States.
出版信息
ACS Chem Neurosci. 2017 Jun 21;8(6):1159-1162. doi: 10.1021/acschemneuro.6b00420. Epub 2017 Mar 6.
The direct visualization of neurotransmitters is a continuing problem in neuroscience; however, functional fluorescent sensors for organic analytes are still rare. Herein, we describe a fluorescent sensor for glutamate and zinc ions. The sensor acts as a fluorescent logic gate, giving a turn-off response to glutamate or zinc ion alone. The combination of analytes produces a large increase in fluorescence. This type of sensor will aid in the study of neurotransmission, in this case, for neurons that copackage high concentrations of zinc and glutamate.
神经递质的直接可视化一直是神经科学中的一个难题；然而，用于有机分析物的功能性荧光传感器仍然很少见。在此，我们描述了一种用于谷氨酸和锌离子的荧光传感器。该传感器作为一个荧光逻辑门，对单独的谷氨酸或锌离子给出关闭响应。分析物的组合会使荧光大幅增加。这种类型的传感器将有助于神经传递的研究，在这种情况下，适用于共包装高浓度锌和谷氨酸的神经元。
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