Baker Amy E, O'Toole George A
Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA
J Bacteriol. 2017 May 25;199(12). doi: 10.1128/JB.00088-17. Print 2017 Jun 15.
Many bacteria move through liquids and across surfaces by using flagella-filaments propelled by a membrane-embedded rotary motor. Much is known about the flagellum: its basic structure, the function of its individual motor components, and the regulation of its synthesis. However, we are only beginning to identify the dynamics of flagellar proteins and to understand how the motor structurally adapts to environmental stimuli. In this review, we discuss the external and cellular factors that influence the dynamics of stator complexes (the ion-conducting channels of the flagellar motor). We focus on recent discoveries suggesting that stator dynamics are a means for controlling flagellar function in response to different environments.
许多细菌通过使用由膜嵌入旋转马达驱动的鞭毛丝在液体中移动并穿过表面。关于鞭毛,我们已经了解很多:它的基本结构、各个马达组件的功能以及其合成的调控。然而,我们才刚刚开始确定鞭毛蛋白的动态变化,并了解马达如何在结构上适应环境刺激。在这篇综述中,我们讨论影响定子复合体(鞭毛马达的离子传导通道)动态变化的外部和细胞因素。我们重点关注最近的发现,这些发现表明定子动态变化是一种响应不同环境来控制鞭毛功能的方式。