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壳聚糖及其衍生物在抗菌和抗真菌方面的最新进展。

Recent developments in antibacterial and antifungal chitosan and its derivatives.

机构信息

Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Campus Coupure, Coupure Links 653, B-9000 Ghent, Belgium.

Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Campus Coupure, Coupure Links 653, B-9000 Ghent, Belgium.

出版信息

Carbohydr Polym. 2017 May 15;164:268-283. doi: 10.1016/j.carbpol.2017.02.001. Epub 2017 Feb 2.

Abstract

Chitosan is the deacetylated form of chitin, a biopolymer that can be obtained from various waste streams and shows antimicrobial activity against different fungi, gram positive and gram negative bacteria. Although chitosan has been studied for years, many aspects remain unclear. This review gives an overview of the antimicrobial activity of chitosan and novel chitosan derivatives of the last 15 years. The most important parameters (molecular weight, degree of deacetylation, etc.) are discussed along with a status update on the mode of action of chitosan.

摘要

壳聚糖是壳聚糖的去乙酰化形式,壳聚糖是一种可以从各种废物流中获得的生物聚合物,对不同的真菌、革兰氏阳性和革兰氏阴性细菌具有抗菌活性。尽管壳聚糖已经研究了多年,但仍有许多方面不清楚。本文综述了壳聚糖及其新型壳聚糖衍生物在过去 15 年中的抗菌活性。讨论了最重要的参数(分子量、脱乙酰度等),并更新了壳聚糖作用模式的现状。

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