Genetic variants and increased risk of meningioma: an updated meta-analysis.

PURPOSE

Various genetic variants have been reported to be linked to an increased risk of meningioma. However, no confirmed conclusion has been obtained. The purpose of the study was to investigate potential meningioma-associated gene polymorphisms, based on published evidence.

MATERIALS AND METHODS

An updated meta-analysis was performed in September 2016. After electronic database searching and study screening, we selected eligible case-control studies and extracted data for meta-analysis, using Mantel-Haenszel statistics. -values, pooled odds ratios (ORs), and 95% confidence intervals were calculated.

RESULTS

We finally selected eight genes with ten polymorphisms: rs12770228, rs1045485, rs1799782, rs25487, rs1801133, rs1801131, rs1801394, rs1805087, 1 null/present, and null/present. Results of meta-analyses showed that there was increased meningioma risk in case groups under all models of rs12770228 (all OR >1, <0.001), compared with control groups. Similar results were observed under the allele, homozygote, dominant, and recessive models of rs1801394 (all OR >1, <0.05), and the heterozygote and dominant models of rs1801131 in the Caucasian population (all OR >1, <0.05). However, no significantly increased meningioma risks were observed for 8 rs1045485, rs25487, rs1799782, rs1801133, rs1805087, or / null mutations.

CONCLUSION

Our updated meta-analysis provided statistical evidence for the role of rs12770228, rs1801394, and rs1801131 in increased susceptibility to meningioma.