Dufour Nicolas, Debarbieux Laurent
Institut Pasteur, groupe interactions bactériophages bactéries chez l'animal, département de microbiologie, 25, rue du Docteur Roux, 75015 Paris, France - Centre hospitalier René Dubos, Service de réanimation médico-chirurgicale, 95500 Pontoise, France.
Institut Pasteur, groupe interactions bactériophages bactéries chez l'animal, département de microbiologie, 25, rue du Docteur Roux, 75015 Paris, France.
Med Sci (Paris). 2017 Apr;33(4):410-416. doi: 10.1051/medsci/20173304011. Epub 2017 May 12.
The continuous increase in antibiotic resistance among bacteria in infectious diseases associated with the lack of new antibiotics able to circumvent them are urging physicians, researchers and politicians to look for others options for treatments. Among those, phage therapy (use of natural viruses that infect bacteria, called bacteriophages) is one of the most promising approaches. In this review, we first focus on the problematic raised by multidrug resistant bacteria before addressing the main biological characteristics of bacteriophages, as well as the credibility and the relevance of phage therapy. We then introduce human applications, their potentials and limits.
与缺乏能够克服细菌耐药性的新型抗生素相关的传染病中,细菌对抗生素的耐药性持续增加,这促使医生、研究人员和政治家去寻找其他治疗选择。其中,噬菌体疗法(使用感染细菌的天然病毒,即噬菌体)是最有前景的方法之一。在这篇综述中,我们首先关注多重耐药细菌引发的问题,然后阐述噬菌体的主要生物学特性,以及噬菌体疗法的可信度和相关性。接着我们介绍其在人类中的应用、潜力和局限性。