基因组编辑与个性化医疗时代的哺乳动物合成生物学
Mammalian synthetic biology in the age of genome editing and personalized medicine.
作者信息
Ho Patrick, Chen Yvonne Y
机构信息
Department of Chemical and Biomolecular Engineering, University of California-Los Angeles, 420 Westwood Plaza, Boelter Hall 5531, Los Angeles, CA 90095, USA.
Department of Chemical and Biomolecular Engineering, University of California-Los Angeles, 420 Westwood Plaza, Boelter Hall 5531, Los Angeles, CA 90095, USA.
出版信息
Curr Opin Chem Biol. 2017 Oct;40:57-64. doi: 10.1016/j.cbpa.2017.06.003. Epub 2017 Jun 16.
The recent expansion of molecular tool kits has propelled synthetic biology toward the design of increasingly sophisticated mammalian systems. Specifically, advances in genome editing, protein engineering, and circuitry design have enabled the programming of cells for diverse applications, including regenerative medicine and cancer immunotherapy. The ease with which molecular and cellular interactions can be harnessed promises to yield novel approaches to elucidate genetic interactions, program cellular functions, and design therapeutic interventions. Here, we review recent advancements in the development of enabling technologies and the practical applications of mammalian synthetic biology.
最近分子工具集的扩展推动了合成生物学朝着设计日益复杂的哺乳动物系统发展。具体而言，基因组编辑、蛋白质工程和电路设计方面的进展使得能够对细胞进行编程以用于多种应用，包括再生医学和癌症免疫疗法。利用分子和细胞相互作用的简便性有望产生阐明基因相互作用、编程细胞功能和设计治疗干预措施的新方法。在这里，我们回顾了使能技术发展的最新进展以及哺乳动物合成生物学的实际应用。
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