脊椎动物皮肤和本体感觉机械转导中的Piezo2
Piezo2 in Cutaneous and Proprioceptive Mechanotransduction in Vertebrates.
作者信息
Anderson E O, Schneider E R, Bagriantsev S N
机构信息
Yale University, New Haven, CT, United States.
出版信息
Curr Top Membr. 2017;79:197-217. doi: 10.1016/bs.ctm.2016.11.002. Epub 2017 Jan 16.
Abstract
Mechanosensitivity is a fundamental physiological capacity, which pertains to all life forms. Progress has been made with regard to understanding mechanosensitivity in bacteria, flies, and worms. In vertebrates, however, the molecular identity of mechanotransducers in somatic and neuronal cells has only started to appear. The Piezo family of mechanogated ion channels marks a pivotal milestone in understanding mechanosensitivity. Piezo1 and Piezo2 have now been shown to participate in a number of processes, ranging from arterial modeling to sensing muscle stretch. In this review, we focus on Piezo2 and its role in mediating mechanosensation and proprioception in vertebrates.
摘要
机械敏感性是一种基本的生理能力，存在于所有生命形式中。在理解细菌、果蝇和蠕虫的机械敏感性方面已取得进展。然而，在脊椎动物中，体细胞和神经元细胞中机械转导器的分子身份才刚刚开始显现。机械门控离子通道的Piezo家族标志着理解机械敏感性的一个关键里程碑。现已证明Piezo1和Piezo2参与了从动脉形成到感知肌肉拉伸等许多过程。在本综述中，我们重点关注Piezo2及其在介导脊椎动物机械感觉和本体感觉中的作用。
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