FoxR2通过抑制p27信号通路促进胶质瘤增殖。
FoxR2 promotes glioma proliferation by suppression of the p27 pathway.
作者信息
Liu Xuejiao, Liu Ning, Yue Chenglong, Wang Dacheng, Qi Zhenglei, Tu Yiming, Zhuang Guokun, Zhou Di, Gao Shangfeng, Niu Mingshan, Yu Rutong
机构信息
Insititute of Nervous System Diseases, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Brain Hospital, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
出版信息
Oncotarget. 2017 Apr 27;8(34):56255-56266. doi: 10.18632/oncotarget.17447. eCollection 2017 Aug 22.
FoxR2 plays an important role in the development of many human tumors. However, the effects of FoxR2 on tumorigenicity of human glioma remain unclear. In this study, we investigated the roles of FoxR2 in cell proliferation and invasion of glioma. We found that overexpression of FoxR2 promoted the proliferation, migration and invasion of glioma cells. Knockout of FoxR2 induced G1 arrest by decreasing the expression levels of cyclin D1, cyclin E and p-Rb. Mechanistically, upregulation of FoxR2 increased the level and activity of MMP-2 and decreased the expression of p27. Furthermore, overexpression of FoxR2 decreased the nuclear accumulation of p27. Taken together, these results indicate that upregulation of FoxR2 may confer enhanced tumorigenicity in glioma cells.
FoxR2在多种人类肿瘤的发展中起着重要作用。然而，FoxR2对人类胶质瘤致瘤性的影响仍不清楚。在本研究中，我们调查了FoxR2在胶质瘤细胞增殖和侵袭中的作用。我们发现FoxR2的过表达促进了胶质瘤细胞的增殖、迁移和侵袭。敲除FoxR2通过降低细胞周期蛋白D1、细胞周期蛋白E和磷酸化Rb的表达水平诱导G1期阻滞。机制上，FoxR2的上调增加了基质金属蛋白酶-2（MMP-2）的水平和活性，并降低了p27的表达。此外，FoxR2的过表达减少了p27的核内积累。综上所述，这些结果表明FoxR2的上调可能赋予胶质瘤细胞增强的致瘤性。
Zotero 插件