人类自然杀伤细胞多样性的广泛范围。
The Broad Spectrum of Human Natural Killer Cell Diversity.
作者信息
Freud Aharon G, Mundy-Bosse Bethany L, Yu Jianhua, Caligiuri Michael A
机构信息
Department of Pathology, The Ohio State University, Columbus, OH 43210, USA; Comprehensive Cancer Center and The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA.
Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA; Comprehensive Cancer Center and The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA.
出版信息
Immunity. 2017 Nov 21;47(5):820-833. doi: 10.1016/j.immuni.2017.10.008.
Natural killer (NK) cells provide protection against infectious pathogens and cancer. For decades it has been appreciated that two major NK cell subsets (CD56 and CD56) exist in humans and have distinct anatomical localization patterns, phenotypes, and functions in immunity. In light of this traditional NK cell dichotomy, it is now clear that the spectrum of human NK cell diversity is much broader than originally appreciated as a result of variegated surface receptor, intracellular signaling molecule, and transcription factor expression; tissue-specific imprinting; and foreign antigen exposure. The recent discoveries of tissue-resident NK cell developmental intermediates, non-NK innate lymphoid cells, and the capacity for NK cells to adapt and differentiate into long-lived memory cells has added further complexity to this field. Here we review our current understanding of the breadth and generation of human NK cell diversity.
自然杀伤（NK）细胞可抵御传染性病原体和癌症。几十年来，人们已经认识到人类存在两种主要的NK细胞亚群（CD56bright和CD56dim），它们在免疫中具有不同的解剖定位模式、表型和功能。鉴于这种传统的NK细胞二分法，现在很清楚，由于表面受体、细胞内信号分子和转录因子表达的多样化、组织特异性印记以及外来抗原暴露，人类NK细胞多样性的范围比最初认识的要广泛得多。最近发现的组织驻留NK细胞发育中间体、非NK固有淋巴细胞以及NK细胞适应并分化为长寿记忆细胞的能力，进一步增加了该领域的复杂性。在此，我们综述了目前对人类NK细胞多样性的广度和产生的理解。
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