睡眠/觉醒调节和调制驱动的神经元机制。
Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive.
机构信息
Department of Psychology, University of Michigan, Ann Arbor, MI, USA.
The Faculty of Life Sciences and the Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel.
出版信息
Neuropsychopharmacology. 2018 Apr;43(5):937-952. doi: 10.1038/npp.2017.294. Epub 2017 Dec 5.
Humans have been fascinated by sleep for millennia. After almost a century of scientific interrogation, significant progress has been made in understanding the neuronal regulation and functions of sleep. The application of new methods in neuroscience that enable the analysis of genetically defined neuronal circuits with unprecedented specificity and precision has been paramount in this endeavor. In this review, we first discuss electrophysiological and behavioral features of sleep/wake states and the principal neuronal populations involved in their regulation. Next, we describe the main modulatory drives of sleep and wakefulness, including homeostatic, circadian, and motivational processes. Finally, we describe a revised integrative model for sleep/wake regulation.
人类对睡眠的痴迷已有数千年的历史。经过近一个世纪的科学探究，人们在理解睡眠的神经元调节和功能方面取得了重大进展。在这一努力中，神经科学中新方法的应用至关重要，这些方法使人们能够以前所未有的特异性和精确性分析遗传定义的神经元回路。在这篇综述中，我们首先讨论了睡眠/觉醒状态的电生理和行为特征，以及参与其调节的主要神经元群体。接下来，我们描述了睡眠和觉醒的主要调节驱动因素，包括内稳态、昼夜节律和动机过程。最后，我们描述了一个修订后的睡眠/觉醒调节综合模型。
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