胎盘衰老在产科并发症和胎儿生长受限的发生中是否起作用？
Is there a role for placental senescence in the genesis of obstetric complications and fetal growth restriction?
机构信息
Mothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, Callaghan, New South Wales, Australia; School of Medicine and Public Health, Faculty of Health and Medicine, University of Newcastle, Callaghan, New South Wales, Australia; Priority Research Centre in Reproductive Science, Faculty of Health and Medicine, Callaghan, New South Wales, Australia.
School of Creative Industries, University of Newcastle, Callaghan, New South Wales, Australia.
出版信息
Am J Obstet Gynecol. 2018 Feb;218(2S):S762-S773. doi: 10.1016/j.ajog.2017.11.567. Epub 2017 Dec 22.
The placenta ages as pregnancy advances, yet its continued function is required for a successful pregnancy outcome. Placental aging is a physiological phenomenon; however, there are some placentas that show signs of aging earlier than others. Premature placental senescence and aging are implicated in a number of adverse pregnancy outcomes, including fetal growth restriction, preeclampsia, spontaneous preterm birth, and intrauterine fetal death. Here we discuss cellular senescence, a state of terminal proliferation arrest, and how senescence is regulated. We also explore the role of physiological placental senescence and how aberrant placental senescence alters placental function, contributing to the pathophysiology of fetal growth restriction, preeclampsia, spontaneous preterm labor/birth, and unexplained fetal death.
胎盘随着妊娠的进展而老化，但为了获得成功的妊娠结局，仍需要胎盘继续发挥功能。胎盘老化是一种生理现象；然而，有些胎盘比其他胎盘更早出现老化迹象。胎盘过早衰老与多种不良妊娠结局有关，包括胎儿生长受限、子痫前期、自发性早产和宫内胎儿死亡。在这里，我们讨论细胞衰老，即一种终末增殖停滞的状态，以及衰老的调控机制。我们还探讨了生理性胎盘衰老的作用，以及异常的胎盘衰老如何改变胎盘功能，导致胎儿生长受限、子痫前期、自发性早产/分娩和不明原因胎儿死亡的病理生理学变化。
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