长非编码 RNA 在神经胶质瘤进展中的作用。
Long non-coding RNAs in glioma progression.
机构信息
Clinical and Translational Research Center of Shanghai First Maternity and Infant Health Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai, 200092, PR China.
Clinical and Translational Research Center of Shanghai First Maternity and Infant Health Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai, 200092, PR China.
出版信息
Cancer Lett. 2018 Apr 10;419:203-209. doi: 10.1016/j.canlet.2018.01.041. Epub 2018 Jan 31.
Glioma is one of most malignant primary tumors of the brain. However, due to a lack of effective means for diagnosing and treating glioma, the prognosis of glioma patients remains poor. Therefore, understanding the molecular mechanism of glioma progression is essential for effective treatment. Long non-coding RNAs (lncRNAs) are novel regulators of gene expression at the transcriptional, post-transcriptional and epigenetic levels. Recent evidence indicates that lncRNAs may play important roles in regulating the progression of glioma. In this article, we review the expression profile of lncRNAs in glioma and discuss the functions and known mechanisms of several representative lncRNAs in detail, as well as the prospects of lncRNAs as diagnostic and prognostic biomarkers and therapeutic targets.
神经胶质瘤是最恶性的脑原发性肿瘤之一。然而，由于缺乏有效的诊断和治疗神经胶质瘤的手段，神经胶质瘤患者的预后仍然较差。因此，了解神经胶质瘤进展的分子机制对于有效治疗至关重要。长链非编码 RNA（lncRNA）是转录、转录后和表观遗传水平上基因表达的新型调控因子。最近的证据表明，lncRNA 可能在调控神经胶质瘤的进展中发挥重要作用。本文综述了 lncRNA 在神经胶质瘤中的表达谱，并详细讨论了几种代表性 lncRNA 的功能和已知机制，以及 lncRNA 作为诊断和预后生物标志物和治疗靶点的前景。
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