可见光诱导的外部自由基引发环化反应构建含 CF 的苯并二氧杂环戊烯衍生物。
Visible-Light-Induced External Radical-Triggered Annulation To Access CF-Containing Benzoxepine Derivatives.
机构信息
College of Chemistry and Chemical Engineering, Central South University , Changsha 410083, China.
College of Chemistry and Materials Science, Guangxi Teachers Education University , Nanning 530000, China.
出版信息
Org Lett. 2018 Mar 2;20(5):1363-1366. doi: 10.1021/acs.orglett.8b00131. Epub 2018 Feb 15.
A facile and diversified synthesis of functionalized CF-containing benzoxepine derivatives via photoredox catalysis was achieved in this work. This novel protocol features broad substrate scope, mild reaction conditions, operational simplicity, easy scale-up, and versatile derivatization, which would facilitate its practical and broad applications in the construction of valuable and synthetically challenging heterocycles.
本文通过光氧化还原催化实现了官能化含 CF 的苯并[B]氧杂环戊烯衍生物的简便、多样化合成。该新方法具有广泛的底物范围、温和的反应条件、操作简单、易于规模化以及多功能衍生化等特点，这将有助于其在构建有价值和具有合成挑战性的杂环方面的实际广泛应用。
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